[HTML][HTML] ESMO expert consensus statements (ECS) on the definition, diagnosis, and management of HER2-low breast cancer

P Tarantino, G Viale, MF Press, X Hu… - Annals of …, 2023‏ - Elsevier
Human epidermal growth factor receptor 2 (HER2)-low breast cancer has recently emerged
as a targetable subset of breast tumors, based on the evidence from clinical trials of novel …

Standardized pathology report for HER2 testing in compliance with 2023 ASCO/CAP updates and 2023 ESMO consensus statements on HER2-low breast cancer

M Ivanova, FM Porta, M D'Ercole, C Pescia, E Sajjadi… - Virchows Archiv, 2024‏ - Springer
Since the release of the DESTINY-Breast04 (DB-04) trial findings in June 2022, the field of
pathology has seen a renaissance of HER2 as a predictive biomarker in breast cancer. The …

Human epidermal growth factor receptor 2 testing in breast cancer: ASCO–College of American Pathologists Guideline Update

AC Wolff, MR Somerfield, M Dowsett… - Journal of Clinical …, 2023‏ - ascopubs.org
PURPOSE To update ASCO–College of American Pathologists (CAP) recommendations for
human epidermal growth factor receptor 2 (HER2) testing in breast cancer. The Panel is …

Clinicopathologic characteristics and prognosis of ERBB2-low breast cancer among patients in the national cancer database

DS Peiffer, F Zhao, N Chen, OM Hahn, R Nanda… - JAMA …, 2023‏ - jamanetwork.com
Importance Given conflicting results regarding the prognosis of erb-b2 receptor tyrosine
kinase 2 (ERBB2; formerly HER2 or HER2/neu)–low breast cancer, a large-scale, nationally …

Human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology–College of American Pathologists Guideline Update

AC Wolff, MR Somerfield, M Dowsett… - … of pathology & …, 2023‏ - meridian.allenpress.com
Purpose.—To update the American Society of Clinical Oncology–College of American
Pathologists (ASCO-CAP) recommendations for human epidermal growth factor receptor 2 …

Comprehensive genomic characterization of HER2-low and HER2-0 breast cancer

P Tarantino, H Gupta, ME Hughes, J Files… - nature …, 2023‏ - nature.com
The molecular underpinnings of HER2-low and HER2-0 (IHC 0) breast tumors remain poorly
defined. Using genomic findings from 1039 patients with HER2-negative metastatic breast …

Comparison of HER2-zero and HER2-low in terms of clinicopathological factors and survival in early-stage breast cancer: A systematic review and meta-analysis

Y Ergun, G Ucar, B Akagunduz - Cancer Treatment Reviews, 2023‏ - Elsevier
Background The prognostic differences between HER2-zero and HER2-low breast cancer
(BC) remain unclear. Purpose of this meta-analysis is to investigate the differences between …

[HTML][HTML] Prognostic value of HER2-low status in breast cancer: a systematic review and meta-analysis

C Molinelli, F Jacobs, E Agostinetto, G Nader-Marta… - ESMO open, 2023‏ - Elsevier
Background Human epidermal growth factor receptor 2 (HER2)-low expression in breast
cancer has been recently identified as a new therapeutic target. However, it is unclear if …

[HTML][HTML] Clinical implications of the intrinsic molecular subtypes in hormone receptor-positive and HER2-negative metastatic breast cancer

C Falato, F Schettini, T Pascual… - Cancer Treatment …, 2023‏ - Elsevier
Traditionally, the classification of breast cancer relies on the expression of
immunohistochemical (IHC) biomarkers readily available in clinical practice. Using highly …

Current biological, pathological and clinical landscape of HER2-low breast cancer

H Zhang, Y Peng - Cancers, 2022‏ - mdpi.com
Simple Summary The breakthrough in develo** novel HER2-targeting antibody drug
conjugates and identifying their clinical benefits in HER2-low breast cancer will dramatically …