Rheumatoid Arthritis — Common Origins, Divergent Mechanisms | New England Journal of
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Inflammation must be tightly regulated to both defend against pathogens and restore tissue
homeostasis. The resolution of inflammatory responses is a dynamic process orchestrated …

In vitro studies have associated oxidative phosphorylation (OXPHOS) with anti-inflammatory
macrophages, whereas pro-inflammatory macrophages rely on glycolysis. However, the …

Type 2 immunity mediates protective responses to helminths and pathological responses to
allergens, but it also has broad roles in the maintenance of tissue integrity, including wound …

The Krebs cycle-derived metabolite itaconate and its derivatives suppress the inflammatory
response in pro-inflammatory" M1" macrophages. However, alternatively activated" M2" …

Tissue‐resident cardiac macrophage subsets mediate cardiac tissue inflammation and
repair after acute myocardial infarction (AMI). CC chemokine receptor 2 (CCR2)‐expressing …

Rheumatoid arthritis (RA) is a global autoimmune disease that requires long-term
management. Ambulatory monitoring and treatment of RA favors remission and …

Nonresolving inflammation contributes to many diseases, including COVID-19 in its fatal and
long forms. Our understanding of inflammation is rapidly evolving. Like the immune system …

Osteoarthritis (OA) is a chronic inflammatory disease characterized by cartilage destruction,
synovitis, and osteophyte formation. Disease‐modifying treatments for OA are currently …

Macrophages may acquire a reparative phenotype that supports tissue repair and
remodeling in response to tissue injury. However, the metabolic requirements underpinning …