Over the past five years, a rapidly develo** experimental approach has enabled high-
resolution and high-content information retrieval from intact multicellular animal (metazoan) …

Spheroids have emerged as in vitro models that reproduce in a great extent the architectural
microenvironment found in human tissues. However, the imaging of 3D cell cultures is highly …

Examination of whole organs with subcellular resolution in health, disease, and during
development is necessary to decipher their biological complexity. However, until recently …

Opaqueness of animal tissue can be attributed mostly to light absorption and light scattering.
In most noncleared tissue samples, confocal images can be acquired at no more than a 100 …

Light-sheet fluorescence microscopy (LSFM) is a minimally invasive and high throughput
imaging technique ideal for capturing large volumes of tissue with sub-cellular resolution. A …

Direct visualization of the spatial relationships of the dental pulp tissue at the whole-organ
has remained challenging. CLARITY (Clear Lipid-exchanged Acrylamide Tissue hYdrogel) …

The endogenous potential of adult neurogenesis is of particular interest for the development
of new strategies for recovery after stroke and traumatic brain injury. These pathological …

Background: Hypoxia is a major obstacle in the treatment of solid tumors because it causes
immune escape and therapeutic resistance. Drug penetration into the hypoxic regions of …

CLARITY is a novel tissue clearing technique that transforms intact biological tissues into a
nanoporous hydrogel‑tissue hybrid, preserving anatomical structures, proteins and nucleic …

In this study, we elucidated for the first time the role of anti-cancer drugs in transarterial
chemoembolization (TACE) via direct visualization of the spatial distribution of drugs with …