Tumour progression is modulated by the local microenvironment. This environment is
populated by many immune cells, of which macrophages are among the most abundant …

Embryo-derived tissue-resident macrophages are the first representatives of the
haematopoietic lineage to emerge in metazoans. In mammals, resident macrophages …

Macrophages are critical regulators of tissue homeostasis but are also abundant in the
tumor microenvironment (TME). In both primary tumors and metastases, such tumor …

Heart failure represents a major cause of morbidity and mortality worldwide. Single-cell
transcriptomics have revolutionized our understanding of cell composition and associated …

Immunological mechanisms have come into the focus of current translational stroke
research, and the modulation of neuroinflammatory pathways has been identified as a …

Resident tissue macrophages (RTMs) have a broad spectrum of immune-and non-immune-
related tissue-supporting activities. The roots of this heterogeneity and versatility are only …

Traditionally, the innate and adaptive immune systems are differentiated by their specificity
and memory capacity. In recent years, however, this paradigm has shifted: Cells of the …

Understanding tissue macrophage biology has become challenging in recent years due the
ever-increasing complexity in macrophage-subset identification and functional …

Sepsis-induced cardiomyopathy (SICM) is common in septic patients with a high mortality
and is characterized by an abnormal immune response. Owing to cellular heterogeneity …

Aside from centrally induced trained immunity in the bone marrow (BM) and peripheral
blood by parenteral vaccination or infection, evidence indicates that mucosal-resident innate …