Haemophilia A and B are rare congenital, recessive X-linked disorders caused by lack or
deficiency of clotting factor VIII (FVIII) or IX (FIX), respectively. The severity of the disease …

Broad interest in develo** new hemostatic technologies arises from unmet needs in
mitigating uncontrolled hemorrhage in emergency, surgical, and battlefield settings …

Background Severe traumatic injury continues to present challenges to healthcare systems
around the world, and post-traumatic bleeding remains a leading cause of potentially …

Background Severe trauma continues to represent a global public health issue and mortality
and morbidity in trauma patients remains substantial. A number of initiatives have aimed to …

Tissue factor (TF) is the high-affinity receptor and cofactor for factor (F) VII/VIIa. The TF-FVIIa
complex is the primary initiator of blood coagulation and plays an essential role in …

CHAIR: Costanzo MR: Midwest Heart Foundation, Lombard Illinois, USA TASK FORCE 1:
Dipchand A: Hospital for Sick Children, Toronto Ontario, Canada; Starling R: Cleveland …

Improvements in the control of haemorrhage after trauma have resulted in the survival of
many people who would otherwise have died from the initial loss of blood. However, the …

Introduction Evidence-based recommendations are needed to guide the acute management
of the bleeding trauma patient. When these recommendations are implemented patient …

Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by
widespread intravascular activation of coagulation that can be caused by infectious insults …

Therapeutic anticoagulation is indicated for a variety of circumstances and conditions in
several fields of medicine to prevent or treat venous and arterial thromboembolism …