Locoregional recurrence negatively impacts both long‐term survival and quality of life for
several malignancies. For appropriate‐risk patients with an isolated, resectable, local …

Simple Summary Solitary fibrous tumor (SFT) is a malignant condition that exhibits different
clinical behaviors ranging from low to high aggressive SFT, with dedifferentiated SFT (DD …

Background The addition of trabectedin to doxorubicin, followed by trabectedin
maintenance, may have superior efficacy to doxorubicin alone as first-line treatment in …

Background Few standard treatment options are available for patients with metastatic
sarcomas. We did this trial to evaluate the efficacy, safety, and changes in the tumour …

Importance Patients with advanced soft tissue sarcoma (STS) have a median overall survival
of less than 2 years. In a phase 2 study, an overall survival benefit in this population was …

Abstract Characterization of the diverse malignant and stromal cell states that make up soft
tissue sarcomas and their correlation with patient outcomes has proven difficult using fixed …

PURPOSE Malignant perivascular epithelioid cell tumor (PEComa) is a rare aggressive
sarcoma, with no approved treatment. To our knowledge, this phase II, single-arm …

Background Evofosfamide is a hypoxia-activated prodrug of bromo-isophosphoramide
mustard. We aimed to assess the benefit of adding evofosfamide to doxorubicin as first-line …

Background Sarcomas exhibit low expression of factors related to immune response, which
could explain the modest activity of PD-1 inhibitors. A potential strategy to convert a cold into …

Angiogenesis has an essential role in tumor growth and metastasis, and blocking this
pathway has been a successfully utilized strategy in the clinical treatment of cancer …