Proteins at interfaces play important roles in cell biology, immunology, bioengineering, and
biomimetic material design. Many biological processes are based on interfacial protein …

Conspectus Chemists have long been fascinated by chirality, water, and interfaces, making
tremendous progress in each research area. However, the chemistry emerging from the …

Understanding the role of water in biological processes remains a central challenge in the
life sciences. Water structures in hydration shells of biomolecules are difficult to study in situ …

Many DNA-based technologies involve the immobilization of DNA and therefore require a
fundamental understanding of the DNA structure–function relationship at interfaces. We …

Biomolecular hydration is fundamental to biological functions. Using phase-resolved chiral
sum-frequency generation spectroscopy (SFG), we probe molecular architectures and …

The application of external electric fields to influence chemical reactions at electrode
interfaces has attracted considerable interest in recent years. However, the design of electric …

We develop an electrostatic map for the vibrational NH stretch (amide A) of the protein
backbone with a focus on vibrational chiral sum frequency generation spectroscopy (chiral …

The chemistry of interfaces differs markedly from that of the bulk. Calculation of interfacial
properties depends strongly on the definition of the interface, which can lead to ambiguous …

Efforts to characterize solid/liquid, solid/gas, liquid/gas, liquid/liquid, and liquid/gas
interfaces utilizing optical spectroscopies in the ultraviolet− visible (UV− vis), infrared (IR) …

The misfolding and aggregation of human islet amyloid polypeptide (hIAPP) at cell
membrane has a close relationship with the development of type 2 diabetes (T2DM). This …