Potent acetylcholinesterase inhibitors: potential drugs for Alzheimer's disease

H Akıncıoğlu, İ Gülçin - Mini reviews in medicinal chemistry, 2020 - ingentaconnect.com
Alzheimer's disease (AD) is one of the cognitive or memory-related impairments occurring
with advancing age. Since its exact mechanism is not known, the full therapy has still not …

LC–MS/MS analysis, antioxidant and anticholinergic properties of galanga (Alpinia officinarum Hance) rhizomes

LP Köse, I Gülcin, AC Gören, J Namiesnik… - Industrial crops and …, 2015 - Elsevier
Abstract Galanga (Alpinia officinarum Hance) is a pungent and aromatic rhizome, which is a
member of the ginger family (Zingiberaceae). The rhizomes of this plant have been used as …

The first synthesis, carbonic anhydrase inhibition and anticholinergic activities of some bromophenol derivatives with S including natural products

C Bayrak, P Taslimi, HS Karaman, I Gulcin… - Bioorganic chemistry, 2019 - Elsevier
Starting from vanillin, known four benzyl bromides with Br were synthesized. The first
synthesis of natural product 3, 4-dibromo-5-((methylsulfonyl) methyl) benzene-1, 2-diol (2) …

Antioxidant and acetylcholinesterase inhibition properties of novel bromophenol derivatives

N Öztaşkın, Y Çetinkaya, P Taslimi, S Göksu… - Bioorganic chemistry, 2015 - Elsevier
In this study, series of novel bromophenol derivatives were synthesized and investigated for
their antioxidant and AChE inhibition properties. Novel brominated diarylmethanones were …

Synthesis of nitrogen, phosphorus, selenium and sulfur-containing heterocyclic compounds–determination of their carbonic anhydrase, acetylcholinesterase …

İ Gülçin, B Trofimov, R Kaya, P Taslimi, L Sobenina… - Bioorganic …, 2020 - Elsevier
Abstract Sulfur-containing pyrroles (1–3), tris (2-pyridyl) phosphine (selenide) sulfide (4–5)
and 4-benzyl-6-(thiophen-2-yl) pyrimidin-2-amine (6) were synthesized and characterized …

Enzymatic assays for the assessment of toxic effects of halogenated organic contaminants in water and food. A review

AE Artabe, H Cunha-Silva, A Barranco - Food and Chemical Toxicology, 2020 - Elsevier
Halogenated organic compounds are a particular group of contaminants consisting of a
large number of substances, and of great concern due to their persistence in the …

Synthesis and carbonic anhydrase isoenzymes I, II, IX, and XII inhibitory effects of dimethoxybromophenol derivatives incorporating cyclopropane moieties

M Boztas, Y Cetinkaya, M Topal, I Gulcin… - Journal of medicinal …, 2015 - ACS Publications
Cyclopropylcarboxylic acids and esters and cyclopropylmethanols incorporating
bromophenol moieties were investigated as inhibitors of the carbonic anhydrase enzyme …

The effect of caffeic acid phenethyl ester (CAPE) on metabolic enzymes including acetylcholinesterase, butyrylcholinesterase, glutathione S-transferase …

İ Gülçin, A Scozzafava, CT Supuran… - Journal of enzyme …, 2016 - Taylor & Francis
Caffeic acid phenethyl ester (CAPE) is an active component of honeybee propolis extracts.
Carbonic anhydrases (CAs, EC 4.2. 1.1) are widespread and intensively studied …

Novel antioxidant bromophenols with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions

N Öztaskın, P Taslimi, A Maraş, İ Gülcin, S Göksu - Bioorganic chemistry, 2017 - Elsevier
In this study, a series of novel bromophenols were synthesized from benzoic acids and
methoxylated bromophenols. The synthesized compounds were evaluated by using different …

Acetylcholinesterase and carbonic anhydrase inhibitory properties of novel urea and sulfamide derivatives incorporating dopaminergic 2-aminotetralin scaffolds

B Özgeriş, S Göksu, LP Köse, I Gülçin… - Bioorganic & medicinal …, 2016 - Elsevier
In the present study a series of urea and sulfamide compounds incorporating the tetralin
scaffolds were synthesized and evaluated for their acetylcholinesterase (AChE), human …