Simple Summary Human health is significantly affected by microbial infections. One of the
largest determinants of the outcomes of such infections is the host immune response. Too …

Sulfation and desulfation of steroids are opposing processes that regulate the activation,
metabolism, excretion, and storage of steroids, which account for steroid homeostasis …

Sepsis pathogenesis is complex and heterogeneous; hence, a precision-medicine strategy
is needed. Acute kidney injury (AKI) following sepsis portends higher mortality …

Sepsis-associated encephalopathy (SAE) is a critical neurological complication of sepsis
and represents a crucial factor contributing to high mortality and adverse prognosis in septic …

Estrogen sulfotransferase (SULT1E1) is a phase II enzyme that sulfates estrogens to
inactivate them and regulate their homeostasis. This enzyme is also involved in the sulfation …

Introduction: Biotransformation is important in the metabolism of endobiotics and
xenobiotics. This process comprises the activity of phase I and phase II enzymes. Estrogen …

Inflammation is a defensive response in the living tissue of the vascular system that acts
against damage factors and involves various types of immune cells, including macrophages …

Recently, there has been increased recognition of the importance of sex as a biological
factor affecting disease and health. Many preclinical studies have suggested that males may …

Background and aim Glucocorticoids are the only first-line drugs for severe alcoholic
hepatitis (AH), with limited efficacy and various side effects on extrahepatic tissues. Liver …

Sepsis is a syndrome of life‐threatening multiorgan dysfunction caused by host response
dysregulation to infection. Ulinastatin (UTI), a serine protease inhibitor, possesses anti …