While there is general agreement on the necessity to measure glomerular filtration rate
(GFR) in many clinical situations, there is less agreement on the best method to achieve this …

Chronic kidney disease (CKD) is prevalent in many countries, and the costs associated with
the care of patients with end-stage renal disease (ESRD) are estimated to exceed US $1 …

Background It is unknown whether stop** renin-angiotensin system (RAS) inhibitor
therapy in patients with advanced CKD affects outcomes. Methods We studied patients …

Background This study was undertaken to determine whether use of the direct renin inhibitor
aliskiren would reduce cardiovascular and renal events in patients with type 2 diabetes and …

Noncommunicable diseases (NCDs) are the most common causes of premature death and
morbidity and have a major impact on health-care costs, productivity, and growth …

Chronic kidney disease is a common disorder and its prevalence is increasing worldwide.
Early diagnosis on the basis of presence of proteinuria or reduced estimated glomerular …

Background Angiotensin receptor blockers (ARB) and angiotensin converting enzyme (ACE)
inhibitors are known to reduce proteinuria. Their combination might be more effective than …

Background Although inhibition of the renin–angiotensin system delays the progression of
renal failure in adults with chronic kidney disease, the blood-pressure target for optimal …

Recent studies emphasize the role of chronic hypoxia in the tubulointerstitium as a final
common pathway to end-stage renal failure. When advanced, tubulointerstitial damage is …

It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …