Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …

Cancer microenvironment is critical for tumorigenesis and cancer progression. The
extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells …

The extracellular matrix (ECM) is an abundant noncellular component of most solid tumors
known to support tumor progression and metastasis. The interplay between the ECM and …

With the global prevalence of type 2 diabetes mellitus steeply rising, instances of chronic,
hard-healing, or non-healing diabetic wounds and ulcers are predicted to increase. The …

Chronic inflammation increases the risk of several cancers, including gastric, colon, and
hepatic cancers. Conversely, tumors, similar to tissue injury, trigger an inflammatory …

Immunotherapy has made significant strides in cancer treatment, particularly through
immune checkpoint blockade (ICB), which has shown notable clinical benefits across …

Osseointegration of implants is a complex physiological process that requires temporal and
spatial regulation of immune responses, angiogenesis, and osteogenesis. To achieve …

A hallmark of pancreatic tumors is their highly desmoplastic stroma composed of fibroblasts,
immune cells, and a dense network of collagen fibers. Tumor-associated macrophages are …

Macrophages and endothelial cells (ECs) have essential roles in physiological and
pathological conditions by regulating inflammation, vascularization and tissue remodelling …

It has been known for decades that the tumor extracellular matrix (ECM) is dysfunctional
leading to loss of tissue architecture and promotion of tumor growth. The altered ECM and …