PECAM-1 (also known as CD31) is a cellular adhesion and signaling receptor comprising
six extracellular immunoglobulin (Ig)-like homology domains, a short transmembrane …

The decrease of endothelial barrier function is central to the long-term inflammatory
response. A pathological alteration of the ability of endothelial cells to modulate the passage …

Biomechanical forces, such as fluid shear stress, govern multiple aspects of endothelial cell
biology. In blood vessels, disturbed flow is associated with vascular diseases, such as …

The migration of neutrophils from the blood circulation to sites of infection or injury is a key
immune response and requires the breaching of endothelial cells (ECs) that line the inner …

BACKGROUND: Systemic inflammatory diseases, such as sepsis and severe COVID-19,
provoke acute respiratory distress syndrome in which the pathological hyperpermeability of …

Platelet endothelial cell adhesion molecule-1 (PECAM-1 or CD31) is a well-known marker of
endothelial cells and a key factor for adhesion and accumulation of platelets. CD31 plays …

Background Cell-derived microparticles are secreted in response to cell damage or
dysfunction. Endothelial and platelet dysfunction are thought to contribute to the …

The blood-brain barrier (BBB) is the tightest endothelial barrier in humans. Characterized by
the presence of tight endothelial junctions and adherens junctions, the primary function of …

The development of physiologically relevant in vitro systems for simulating disease onset
and progression and predicting drug metabolism holds tremendous value in reducing drug …

Cells depend on precisely regulating barrier function within the vasculature to maintain
physiological stability and facilitate essential substance transport. Endothelial cells achieve …