The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical
and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is …

During cell migration, the forces generated in the actin cytoskeleton are transmitted across
transmembrane receptors to the extracellular matrix or other cells through a series of …

In their roles as major adhesion receptors, integrins signal across the plasma membrane in
both directions. Recent structural and cell biological data suggest models for how integrins …

Cell-directed changes in the ligand-binding affinity ('activation') of integrins regulate cell
adhesion and migration, extracellular matrix assembly and mechanotransduction, thereby …

Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their
most prominent features are interdigitated foot processes with filtration slits in between …

Integrins are cell adhesion molecules that mediate cell-cell, cell–extracellular matrix, and
cell-pathogen interactions. They play critical roles for the immune system in leukocyte …

Poor cell adhesion to orthopaedic and dental implants may result in implant failure. Cellular
adhesion to biomaterial surfaces primarily is mediated by integrins, which act as signal …

Blood vessels promote tumour growth, and both blood and lymphatic vessels facilitate
tumour metastasis by serving as conduits for the transport of tumour cells to new sites …

Control of integrin affinity for ligands (integrin activation) is essential for normal cell
adhesion, migration, and assembly of an extracellular matrix. Integrin activation is usually …

We have determined the crystal structure of a complex between the I domain of integrin
α2β1 and a triple helical collagen peptide containing a critical GFOGER motif. Three loops …