Nearly half a century has passed since the discovery of cytoplasmic inheritance of human
chloramphenicol resistance. The inheritance was then revealed to take place maternally by …

Normal brain functioning relies on high aerobic energy production provided by
mitochondria. Failure to supply a sufficient amount of energy, seen in different brain …

We assembled a semi-automated reconstruction of L2/3 mouse primary visual cortex from∼
250× 140× 90 μm 3 of electron microscopic images, including pyramidal and non-pyramidal …

Mitochondria play many important biological roles, including ATP production, lipid
biogenesis, ROS regulation, and calcium clearance. In neurons, the mitochondrion is an …

Schizophrenia is a complex, chronic mental health disorder whose heterogeneous genetic
and neurobiological background influences early brain development, and whose precise …

The brain is one of the most energy-consuming organs in the mammalian body, and
synaptic transmission is one of the major contributors. To meet these energetic …

Background Emerging evidence points to a central role of mitochondria in psychiatric
disorders. However, little is known about the molecular players that regulate mitochondria in …

The brain's ability to process complex information relies on the constant supply of energy
through aerobic respiration by mitochondria. Neurons contain three anatomically distinct …

Prolonging the healthy life span and limiting neurological illness are imperative goals in
gerontology. Age-related neurodegeneration is progressive and leads to severe diseases …

Synapses are pivotal sites of plasticity and memory formation. Consequently, synapses are
energy consumption hotspots susceptible to dysfunction when their energy supplies are …