The inquisitiveness about what happens in the brain has been there since the beginning of
humankind. Functional magnetic resonance imaging is a prominent tool which helps in the …

Within the field of computational neuroscience there are great expectations of finding new
ways to rebalance the complex dynamic system of the human brain through controlled …

Commonly used for Parkinson's disease (PD), deep brain stimulation (DBS) produces
marked clinical benefits when optimized. However, assessing the large number of possible …

Abstract Dynamic Causal Modelling (DCM) is the predominant method for inferring effective
connectivity from neuroimaging data. In the 15 years since its introduction, the neural …

Deep brain stimulation (DBS) is an effective treatment and has provided unique insights into
the dynamic circuit architecture of brain disorders. This Review illustrates our current …

The process of altering neural activity–neuromodulation–has long been used to treat
patients with brain disorders and answer scientific questions. Deep brain stimulation in …

Deep brain stimulation (DBS) has been successfully used to treat movement disorders, such
as Parkinson's disease, for more than 25 years and heralded the advent of electrical …

In the long-term, with progression of the illness, Parkinson's disease dementia affects up to
90% of patients with Parkinson's disease. With increasing life expectancy in western …

Objectives Firstly, to identify subthalamic region stimulation clusters that predict maximum
improvement in rigidity, bradykinesia and tremor, or emergence of side-effects; and …

Biomarkers in whichever modality are tremendously important in diagnosing of disease,
tracking disease progression and clinical trials. This applies in particular for disorders with a …