Spatial map** of the DNA adducts in cancer
KL Krieger, EK Mann, KJ Lee, E Bolterstein… - DNA repair, 2023 - Elsevier
DNA adducts and strand breaks are induced by various exogenous and endogenous
agents. Accumulation of DNA damage is implicated in many disease processes, including …
agents. Accumulation of DNA damage is implicated in many disease processes, including …
Discovery of a far-red carbazole-benzoindolium fluorescent ligand that selectively targets mitochondrial DNA and suppresses breast cancer growth
Abstract G-quadruplex (G4) formation was considered to be more prevalent in the
mitochondrial DNA (mtDNA) of cancer cells compared with normal cells. Stabilization of …
mitochondrial DNA (mtDNA) of cancer cells compared with normal cells. Stabilization of …
DNA sequence and lesion-dependent mitochondrial transcription factor A (TFAM)-DNA-binding modulates DNA repair activities and products
K Urrutia, YH Chen, J Tang, TI Hung… - Nucleic Acids …, 2024 - academic.oup.com
Mitochondrial DNA (mtDNA) is indispensable for mitochondrial function and is maintained
by DNA repair, turnover, mitochondrial dynamics and mitophagy, along with the inherent …
by DNA repair, turnover, mitochondrial dynamics and mitophagy, along with the inherent …
A highly emissive near infrared thiophene-benzoindolium ligand binding to mitochondrial G-quadruplexes triggers triple-negative breast cancer cell death
XD Wang, YS Liu, MH Hu - Sensors and Actuators B: Chemical, 2024 - Elsevier
Small-molecule fluorescent ligands targeting mitochondrial G-quadruplexes (mtG4s) are
considered as a promising direction in tumor therapy, especially those with dual roles of …
considered as a promising direction in tumor therapy, especially those with dual roles of …
Chemoenzymatic Installation of Site-Specific Chemical Groups on DNA Enhances the Catalytic Activity
Z Zhang, W Wei, S Chen, J Yang, D Song… - Journal of the …, 2024 - ACS Publications
Functional DNAs are valuable molecular tools in chemical biology and analytical chemistry
but suffer from low activities due to their limited chemical functionalities. Here, we present a …
but suffer from low activities due to their limited chemical functionalities. Here, we present a …
[HTML][HTML] Activation of Sirtuin3 by honokiol ameliorates alveolar epithelial cell senescence in experimental silicosis via the cGAS-STING pathway
Q Zhou, G Yi, M Chang, N Li, Y Bai, H Li, S Yao - Redox Biology, 2024 - Elsevier
Background Silicosis, characterized by interstitial lung inflammation and fibrosis, poses a
significant health threat. ATII cells play a crucial role in alveolar epithelial repair and …
significant health threat. ATII cells play a crucial role in alveolar epithelial repair and …
Ultrafast Reaction of the Drug Hydralazine with Apurinic/Apyrimidinic Sites in DNA Gives Rise to a Stable Triazolo[3,4-a]phthalazine Adduct
T Islam, G Shim, D Melton, CD Lewis… - Chemical Research …, 2024 - ACS Publications
The clinically used antihypertensive agent hydralazine rapidly generates hydrazone-derived
adducts by reaction with apurinic/apyrimidinic (also known as abasic or AP) sites in many …
adducts by reaction with apurinic/apyrimidinic (also known as abasic or AP) sites in many …
Honokiol ameliorates silica-induced lung fibrosis by inhibiting macrophage pyroptosis via modulating cGAS/STING signaling
Q Zhou, M Chang, S Guo, Y Zhang, Q Qu… - International …, 2025 - Elsevier
Silicosis is a life-threatening occupational disease because of inhaling silica dust, leading to
chronic inflammation, pyroptosis, and fibrosis. Unfortunately, it is still lacking effective …
chronic inflammation, pyroptosis, and fibrosis. Unfortunately, it is still lacking effective …
[PDF][PDF] Oxidatively damaged RNA: investigating the impact of oxidative stress on a molecular level
M Weber - openscience.ub.uni-mainz.de
1 ABSTRACT RNA plays a pivotal role in gene expression, participating in transcription,
translation, and various regulatory processes. Its integrity, structural stability, and …
translation, and various regulatory processes. Its integrity, structural stability, and …