Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities
Pain medication plays an important role in the treatment of acute and chronic pain
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …
The silent epidemic of chronic pain in older adults
Chronic pain is highly prevalent among older adults where it is associated with significant
suffering, disability, social isolation, and greater costs and burden to health care systems …
suffering, disability, social isolation, and greater costs and burden to health care systems …
Low back pain in older adults: risk factors, management options and future directions
Low back pain (LBP) is one of the major disabling health conditions among older adults
aged 60 years or older. While most causes of LBP among older adults are non-specific and …
aged 60 years or older. While most causes of LBP among older adults are non-specific and …
Pain assessment in elderly adults with dementia
Chronic pain is highly prevalent in the ageing population. Individuals with neurological
disorders such as dementia are susceptible patient groups in which pain is frequently under …
disorders such as dementia are susceptible patient groups in which pain is frequently under …
Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's disease
Resting-state or intrinsic connectivity network functional magnetic resonance imaging
provides a new tool for map** large-scale neural network function and dysfunction …
provides a new tool for map** large-scale neural network function and dysfunction …
Functional connectivity of the insula in the resting brain
The human insula is hidden in the depth of the cerebral hemisphere by the overlying frontal
and temporal opercula, and consists of three cytoarchitectonically distinct regions: the …
and temporal opercula, and consists of three cytoarchitectonically distinct regions: the …
Pain management in patients with dementia
WP Achterberg, MJC Pieper… - … interventions in aging, 2013 - Taylor & Francis
There are an estimated 35 million people with dementia across the world, of whom 50%
experience regular pain. Despite this, current assessment and treatment of pain in this …
experience regular pain. Despite this, current assessment and treatment of pain in this …
Chronic pain in the elderly: mechanisms and distinctive features
A Tinnirello, S Mazzoleni, C Santi - Biomolecules, 2021 - mdpi.com
Background: Chronic pain is a major issue affecting more than 50% of the older population
and up to 80% of nursing homes residents. Research on pain in the elderly focuses mainly …
and up to 80% of nursing homes residents. Research on pain in the elderly focuses mainly …
A biopsychosocial formulation of pain communication.
We present a detailed framework for understanding the numerous and complicated
interactions among psychological and social determinants of pain through examination of …
interactions among psychological and social determinants of pain through examination of …
Neuroimaging of the periaqueductal gray: state of the field
This review and meta-analysis aims at summarizing and integrating the human
neuroimaging studies that report periaqueductal gray (PAG) involvement; 250 original …
neuroimaging studies that report periaqueductal gray (PAG) involvement; 250 original …