Three-dimensional multicellular tumor models are receiving an ever-growing focus as
preclinical drug-screening platforms due to their potential to recapitulate major physiological …

Acute myeloid leukemia (AML) is a heterogeneous malignancy affecting myeloid cells in the
bone marrow (BM) but can spread giving rise to impaired hematopoiesis. AML incidence …

The failure of the osteosarcoma conventional therapies leads to the growing need for novel
therapeutic strategies. The lack of specificity for the Cancer Stem Cells (CSCs) population …

Titanium dioxide nanoparticles (TiO2 NPs) are regularly used in sunscreens because of
their photoprotective capacity. The advantage of using TiO2 on the nanometer scale is due …

The bone is a frequent metastatic site, with changes in the mineralized bone and the bone
marrow milieu that can also prime other sites for metastasis by educating progenitor cells to …

Abstract A two-dimensional (2D) cell culture-based model is widely applied to study
tumorigenic mechanisms and drug screening. However, it cannot authentically simulate the …

In the last decade, three-dimensional (3D) cell culture technology has gained a lot of interest
due to its ability to better recapitulate the in vivo organization and microenvironment of in …

Cancer metastasis to bone is a three-dimensional (3D), multistep, dynamic process that
requires the sequential involvement of three microenvironments, namely, the primary tumour …

Starting from their role exerted on osteoblast and osteoclast differentiation and activity
pathways, microRNAs (miRNAs) have been recently identified as regulators of different …

Bone metastasis is considered as a considerable challenge for breast cancer patients.
Various in vitro and in vivo models have been developed to examine this occurrence. In vitro …