Functional genes and proteins of Trichinella spp.
I Nagano, Z Wu, Y Takahashi - Parasitology research, 2009 - Springer
Research of Trichinella proteins has been conducted with emphasis on excretory–secretory
(E–S) products of muscle larvae because of two reasons. The first is that it has prominent …
(E–S) products of muscle larvae because of two reasons. The first is that it has prominent …
Pyrimidine metabolism in schistosomes: A comparison with other parasites and the search for potential chemotherapeutic targets
MH El Kouni - Comparative Biochemistry and Physiology Part B …, 2017 - Elsevier
Schistosomes are responsible for the parasitic disease schistosomiasis, an acute and
chronic parasitic ailment that affects> 240 million people in 70 countries worldwide. It is the …
chronic parasitic ailment that affects> 240 million people in 70 countries worldwide. It is the …
Phosphorylation of thymidylate synthase affects slow-binding inhibition by 5-fluoro-dUMP and N 4-hydroxy-dCMP
Endogenous thymidylate synthases, isolated from tissues or cultured cells of the same
specific origin, have been reported to show differing slow-binding inhibition patterns. These …
specific origin, have been reported to show differing slow-binding inhibition patterns. These …
Developmental arrest in Caenorhabditis elegans dauer larvae causes high expression of enzymes involved in thymidylate biosynthesis, similar to that found in …
Crude extract specific activities of thymidylate synthase, dUTPase, thymidine kinase and
dihydrofolate reductase were high during the development of Caenorhabditis elegans, the …
dihydrofolate reductase were high during the development of Caenorhabditis elegans, the …
Trichinella spiralis thymidylate synthase: cDNA cloning and sequencing, and developmental pattern of mRNA expression
M Dąbrowska, E Jagielska, J Cieśla, A Płucienniczak… - Parasitology, 2004 - cambridge.org
The persistent expression of thymidylate synthase activity has previously been
demonstrated not only in adult forms, but also in non-develo** muscle larvae of Trichinella …
demonstrated not only in adult forms, but also in non-develo** muscle larvae of Trichinella …
Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular …
Three crystal structures are presented of nematode thymidylate synthases (TS), including
Caenorhabditis elegans (Ce) enzyme without ligands and its ternary complex with dUMP …
Caenorhabditis elegans (Ce) enzyme without ligands and its ternary complex with dUMP …
Crystal structures of complexes of mouse thymidylate synthase crystallized with N4-OH-dCMP alone or in the presence of N5,10-methylenetetrahydrofolate
A Dowierciał, A Jarmuła, P Wilk, W Rypniewski… - Pteridines, 2013 - degruyter.com
To solve the inhibition mechanism of thymidylate synthase (TS) by N4-hydroxy-dCMP (N4-
OH-dCMP), crystallographic studies were undertaken. Structures of three mouse TS (mTS) …
OH-dCMP), crystallographic studies were undertaken. Structures of three mouse TS (mTS) …
[PDF][PDF] Developmental arrest in Caenorhabditis elegans dauer larvae causes high expression of enzymes involved in thymidylate biosynthesis, similar to that found in …
Crude extract specific activities of thymidylate synthase, dUTPase, thymidine kinase and
dihydrofolate reductase were high during the development of Caenorhabditis elegans, the …
dihydrofolate reductase were high during the development of Caenorhabditis elegans, the …
Interaction of thymidylate synthase with the 5´-thiophosphates, 5´-dithiophosphates, 5´-H-phosphonates and 5´-S-thiosulfates of 2´-deoxyuridine, thymidine and 5 …
B Golos, JM Dzik, Z Kazimierczuk, J Ciesla, Z Zielinski… - 2001 - degruyter.com
New analogs of dUMP, dTMP and 5-fluorodUMP, including the corresponding
5thiophosphates (dUMPS, dTMPS and FdUMPS), 5dithiophosphates (dUMPS2, dTMPS2 …
5thiophosphates (dUMPS, dTMPS and FdUMPS), 5dithiophosphates (dUMPS2, dTMPS2 …
Alvaxanthone, a thymidylate synthase inhibitor with nematocidal and tumoricidal activities
With the aim to identify novel inhibitors of parasitic nematode thymidylate synthase (TS), we
screened in silico an in-house library of natural compounds, taking advantage of a model of …
screened in silico an in-house library of natural compounds, taking advantage of a model of …