Breast cancer is associated with the second highest cancer-associated deaths worldwide.
Therefore, understanding the key events that determine breast cancer progression …

Breast cancer (BC) has been ranked the most common malignant tumor throughout the
world and is also a leading cause of cancer-related deaths among women. SRC family …

The skin is a squamous epithelium that is continuously renewed by a population of basal
layer stem/progenitor cells and can heal wounds. Here, we show that the transcription …

Activation of the tyrosine kinase c-Src promotes breast cancer progression and poor
outcomes, yet the underlying mechanisms are incompletely understood. Here, we have …

The members of the Src family of nonreceptor tyrosine kinases (SFKs) are implicated in
multiple signaling processes that regulate key cellular functions, including proliferation …

We have previously shown that lipoma preferred partner (LPP) mediates TGFβ-induced
breast cancer cell migration and invasion. Herein, we demonstrate that diminished LPP …

Protein kinase A (PKA) hyperactivation causes hereditary endocrine neoplasias; however,
its role in sporadic epithelial cancers is unknown. Here, we show that heightened PKA …

Integrin receptors coordinate cell adhesion to the extracellular matrix (ECM) to facilitate
many cellular processes during malignant transformation. Despite their pro-tumorigenic …

Background Triple-negative breast cancer (TNBC) tumors are composed of a
heterogeneous population containing both cancer cells and cancer stem cells (CSCs) …

Although ERBB2 amplification and overexpression is correlated with poor outcome in breast
cancer, the molecular mechanisms underlying the aggressive nature of these tumors has not …