Major obstacles to doxorubicin therapy: Cardiotoxicity and drug resistance
HS Al-Malky, SE Al Harthi… - Journal of Oncology …, 2020 - journals.sagepub.com
Background Doxorubicin is one of the most commonly prescribed and time-tested anticancer
drugs. Although being considered as a first line drug in different types of cancers, the two …
drugs. Although being considered as a first line drug in different types of cancers, the two …
[HTML][HTML] Current state of phenolic and terpenoidal dietary factors and natural products as non-coding RNA/microRNA modulators for improved cancer therapy and …
B Biersack - Non-coding RNA research, 2016 - Elsevier
The epigenetic regulation of cancer cells by small non-coding RNA molecules, the
microRNAs (miRNAs), has raised particular interest in the field of oncology. These miRNAs …
microRNAs (miRNAs), has raised particular interest in the field of oncology. These miRNAs …
Hyaluronic acid-coated PEI-PLGA nanoparticles mediated co-delivery of doxorubicin and miR-542-3p for triple negative breast cancer therapy
MicroRNAs (miRNAs) play critical roles in modulating the oncogenic driver pathways
involved in the acquisition of resistance to cancer treatments. MiR-542-3p serves as a potent …
involved in the acquisition of resistance to cancer treatments. MiR-542-3p serves as a potent …
The miRNA-449 family mediates doxorubicin resistance in triple-negative breast cancer by regulating cell cycle factors
E Tormo, S Ballester, A Adam-Artigues, O Burgués… - Scientific reports, 2019 - nature.com
The mechanisms of chemotherapy resistance in triple negative breast cancer remain
unclear, and so, new molecules which might mediate this resistance could optimize …
unclear, and so, new molecules which might mediate this resistance could optimize …
[HTML][HTML] Insights into molecular mechanisms of chemotherapy resistance in cancer
Cancer heterogeneity poses a significant hurdle to the successful treatment of the disease,
and is being influenced by genetic inheritance, cellular and tissue biology, disease …
and is being influenced by genetic inheritance, cellular and tissue biology, disease …
Novel Siglec-15-Sia axis inhibitor leads to colorectal cancer cell death by targeting miR-6715b-3p and oncogenes
Siglecs are well known immunotherapeutic targets in cancer. Current checkpoint inhibitors
have exhibited limited efficacy, prompting a need for novel therapeutics for targets such as …
have exhibited limited efficacy, prompting a need for novel therapeutics for targets such as …
MicroRNA-92a promotes growth, metastasis, and chemoresistance in non-small cell lung cancer cells by targeting PTEN
P Ren, F Gong, Y Zhang, J Jiang, H Zhang - Tumor Biology, 2016 - Springer
Abstract MicroRNA-92a (miR-92a) has been reported to play important roles in
tumorigenesis of human various cancers. However, the roles and underlying molecular …
tumorigenesis of human various cancers. However, the roles and underlying molecular …
miR-200c increases the sensitivity of breast cancer cells to Doxorubicin through downregulating MDR1 gene
Background Breast cancer (BC) has been known as the most common type of cancer
worldwide and resulted in death among women. BC is usually resistant to standard …
worldwide and resulted in death among women. BC is usually resistant to standard …
Combination of Metformin, Sodium Oxamate and Doxorubicin Induces Apoptosis and Autophagy in Colorectal Cancer Cells via Downregulation HIF-1α
J Coronel-Hernández, R Salgado-García… - Frontiers in …, 2021 - frontiersin.org
Colorectal cancer (CRC) is the third leading cause of cancer-related death worldwide in
both sexes. Current therapies include surgery, chemotherapy, and targeted therapy; …
both sexes. Current therapies include surgery, chemotherapy, and targeted therapy; …
miR-197-5p increases Doxorubicin-mediated anticancer cytotoxicity of HT1080 fibrosarcoma cells by decreasing drug efflux
Doxorubicin (Dox) is one of the most used drugs in the treatment of Soft tissue sarcoma.
However, acquired resistance linked with poor survival and numerous side effects are the …
However, acquired resistance linked with poor survival and numerous side effects are the …