Central nervous system neurons communicate via fast synaptic transmission mediated by
ligand-gated ion channel (LGIC) receptors and slower neuromodulation mediated by G …

Addiction is a complex disease that impacts millions of people around the world. Clinically,
addiction is formalized as substance use disorder (SUD), with three primary symptom …

Disrupted operations of the reward circuit underlie major emotional disorders, including
depression, which commonly arise following early life stress/adversity (ELA). However, how …

Deposition of amyloid-β (Aβ) in the brain can impair neuronal function and contribute to
cognitive decline in Alzheimer's disease (AD). Here, we found that dopamine and the …

Drugs of abuse induce persistent remodeling of reward circuit function, a process thought to
underlie the emergence of drug craving and relapse to drug use. However, how circuit …

Suppression of dangerous or inappropriate reward-motivated behaviors is critical for
survival, whereas therapeutic or recreational opioid use can unleash detrimental behavioral …

Addiction is a chronic relapsing disorder with devastating personal, societal, and economic
consequences. In humans, early‐life adversity (ELA) such as trauma, neglect, and resource …

Lack of behavioral suppression typifies substance use disorders, yet the neural circuit
underpinnings of drug-induced behavioral disinhibition remain unclear. Here, we employ …

Regulation of axonal dopamine release by local microcircuitry is at the hub of several
biological processes that govern the timing and magnitude of signaling events in reward …

In humans, early-life adversity (ELA) such as trauma, poverty, and chaotic environment is
linked to increased risk of later-life emotional disorders including depression and substance …