Innate immunity to Toxoplasma gondii infection

F Yarovinsky - Nature Reviews Immunology, 2014 - nature.com
Toxoplasma gondii is a protozoan parasite of global importance. In the laboratory setting, T.
gondii is frequently used as a model pathogen to study mechanisms of T helper 1 (TH1) cell …

Immune response and immunopathology during toxoplasmosis

CD Dupont, DA Christian, CA Hunter - Seminars in immunopathology, 2012 - Springer
Toxoplasma gondii is a protozoan parasite of medical and veterinary significance that is
able to infect any warm-blooded vertebrate host. In addition to its importance to public …

Type II Toxoplasma gondii KU80 Knockout Strains Enable Functional Analysis of Genes Required for Cyst Development and Latent Infection

BA Fox, A Falla, LM Rommereim, T Tomita… - Eukaryotic …, 2011 - journals.asm.org
ABSTRACT Type II Toxoplasma gondii KU80 knockouts (Δ ku80) deficient in
nonhomologous end joining were developed to delete the dominant pathway mediating …

Marginal zone B cells regulate antigen-specific T cell responses during infection

R Bankoti, K Gupta, A Levchenko… - The Journal of …, 2012 - journals.aai.org
Marginal zone B cells (MZB) participate in the early immune response to several pathogens.
In this study, we show that in μMT mice infected with Leishmania donovani, CD8 T cells …

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection

D VanDyke, M Iglesias, J Tomala, A Young, J Smith… - Cell reports, 2022 - cell.com
Summary Low-dose human interleukin-2 (hIL-2) treatment is used clinically to treat
autoimmune disorders due to the cytokine's preferential expansion of immunosuppressive …

Complex immune cell interplay in the gamma interferon response during Toxoplasma gondii infection

CR Sturge, F Yarovinsky - Infection and immunity, 2014 - journals.asm.org
Toxoplasma gondii is an obligate intracellular parasite of clinical importance, especially in
immunocompromised patients. Investigations into the immune response to the parasite …

Persistence of Toxoplasma gondii in the central nervous system: a fine‐tuned balance between the parasite, the brain and the immune system

N Blanchard, IR Dunay, D Schlüter - Parasite immunology, 2015 - Wiley Online Library
Upon infection of humans and animals with Toxoplasma gondii, the parasites persist as
intraneuronal cysts that are controlled, but not eliminated by the immune system. In …

Toxoplasma gondii: CD8 T Cells Cry for CD4 Help

IA Khan, SJ Hwang, M Moretto - Frontiers in cellular and infection …, 2019 - frontiersin.org
Toxoplasma gondii, an apicomplexan parasite, is a pathogenic protozoan that can infect the
central nervous system. In pregnant women, infection can result in congenital problems of …

Interferon-gamma-and perforin-mediated immune responses for resistance against Toxoplasma gondii in the brain

Y Suzuki, Q Sa, M Gehman, E Ochiai - Expert reviews in molecular …, 2011 - cambridge.org
Toxoplasma gondii is an obligate intracellular protozoan parasite that causes various
diseases, including lymphadenitis, congenital infection of fetuses and life-threatening …

Global status of Toxoplasma gondii infection and associated risk factors in people living with HIV

H Safarpour, M Cevik, M Zarean, A Barac… - Aids, 2020 - journals.lww.com
Objective: Toxoplasma infection remains as the most common cause of focal brain lesions
among people living with HIV (PLHIV) despite the decline in opportunistic infections with the …