Increased expression of readthrough acetylcholinesterase variants in the brains of Alzheimer's disease patients

ML Campanari, F Navarrete… - Journal of …, 2016 - journals.sagepub.com
Alzheimer's disease (AD) is characterized by a decrease in the enzymatic activity of the
enzyme acetylcholinesterase (AChE). AChE is expressed as multiple splice variants, which …

Genome-wide methylation map** using nanopore sequencing technology identifies novel tumor suppressor genes in hepatocellular carcinoma

CF Davenport, T Scheithauer, A Dunst, FS Bahr… - International Journal of …, 2021 - mdpi.com
Downregulation of multiple tumor suppressor genes (TSGs) plays an important role in
cancer formation. Recent evidence has accumulated that cancer progression involves …

Glycosylation of TRPM4 and TRPM5 channels: molecular determinants and functional aspects

NRM Syam, JS Rougier, H Abriel - Biophysical Journal, 2014 - cell.com
Glycosylation of TRPM4 and TRPM5 Channels: Molecular Determinants and Functional
Aspects Page 1 view that cytoskeletal structures in cells are defined not only by their …

Cloning, expression, and characterization of human brain acetylcholinesterase in Escherichia coli using a SUMO fusion tag

H Ceylan, O Erdoğan - Turkish Journal of Biology, 2017 - journals.tubitak.gov.tr
The molecular structure of acetylcholinesterase (AChE) attracts interest because of its
versatility and significant role in the cholinergic system. The main purpose of the present …

N‐linked glycosylation of dimeric acetylcholinesterase in erythrocytes is essential for enzyme maturation and membrane targeting

WKW Luk, VP Chen, RCY Choi, KWK Tsim - The FEBS journal, 2012 - Wiley Online Library
Acetylcholinesterase (AChE) is well‐known for its cholinergic functions in the nervous
system; however, this enzyme is also found in other tissues where its function is still not …

Presenilin-1 influences processing of the acetylcholinesterase membrane anchor PRiMA

MS García-Ayllón, ML Campanari, MF Montenegro… - Neurobiology of …, 2014 - Elsevier
Abstract Presenilin-1 (PS1) is the catalytic component of the γ-secretase complex. In this
study, we explore if PS1 participates in the processing of the cholinergic …