Phages for phage therapy: isolation, characterization, and host range breadth
P Hyman - Pharmaceuticals, 2019 - mdpi.com
For a bacteriophage to be useful for phage therapy it must be both isolated from the
environment and shown to have certain characteristics beyond just killing strains of the …
environment and shown to have certain characteristics beyond just killing strains of the …
Molecular and evolutionary determinants of bacteriophage host range
The host range of a bacteriophage is the taxonomic diversity of hosts it can successfully
infect. Host range, one of the central traits to understand in phages, is determined by a range …
infect. Host range, one of the central traits to understand in phages, is determined by a range …
[HTML][HTML] Engineering phage host-range and suppressing bacterial resistance through phage tail fiber mutagenesis
The rapid emergence of antibiotic-resistant infections is prompting increased interest in
phage-based antimicrobials. However, acquisition of resistance by bacteria is a major issue …
phage-based antimicrobials. However, acquisition of resistance by bacteria is a major issue …
More is better: selecting for broad host range bacteriophages
Bacteriophages are viruses that infect bacteria. In this perspective, we discuss several
aspects of a characteristic feature of bacteriophages, their host range. Each phage has its …
aspects of a characteristic feature of bacteriophages, their host range. Each phage has its …
Phage-specific metabolic reprogramming of virocells
Ocean viruses are abundant and infect 20–40% of surface microbes. Infected cells, termed
virocells, are thus a predominant microbial state. Yet, virocells and their ecosystem impacts …
virocells, are thus a predominant microbial state. Yet, virocells and their ecosystem impacts …
Engineered reporter phages for detection of Escherichia coli, Enterococcus, and Klebsiella in urine
S Meile, J Du, S Staubli, S Grossmann… - Nature …, 2023 - nature.com
The rapid detection and species-level differentiation of bacterial pathogens facilitates
antibiotic stewardship and improves disease management. Here, we develop a rapid …
antibiotic stewardship and improves disease management. Here, we develop a rapid …
Freshwater viral metagenome reveals novel and functional phage-borne antibiotic resistance genes
Background Antibiotic resistance developed by bacteria is a significant threat to global
health. Antibiotic resistance genes (ARGs) spread across different bacterial populations …
health. Antibiotic resistance genes (ARGs) spread across different bacterial populations …
Enhanced mutualistic symbiosis between soil phages and bacteria with elevated chromium-induced environmental stress
Background Microbe–virus interactions have broad implications on the composition,
function, and evolution of microbiomes. Elucidating the effects of environmental stresses on …
function, and evolution of microbiomes. Elucidating the effects of environmental stresses on …
In vitro techniques and measurements of phage characteristics that are important for phage therapy success
T Glonti, JP Pirnay - Viruses, 2022 - mdpi.com
Validated methods for phage selection, host range expansion, and lytic activity
determination are indispensable for maximizing phage therapy outcomes. In this review, we …
determination are indispensable for maximizing phage therapy outcomes. In this review, we …
Changes in tetracycline partitioning and bacteria/phage-comediated ARGs in microplastic-contaminated greenhouse soil facilitated by sophorolipid
The emerging mixed contamination of antibiotics and microplastics in greenhouse soil has
made the control of antibiotic resistant gene (ARG) transmission a novel challenge. In this …
made the control of antibiotic resistant gene (ARG) transmission a novel challenge. In this …