Mass spectrometry-based proteomics as an emerging tool in clinical laboratories

AG Birhanu - Clinical proteomics, 2023 - Springer
Mass spectrometry (MS)-based proteomics have been increasingly implemented in various
disciplines of laboratory medicine to identify and quantify biomolecules in a variety of …

Detecting post-translational modification signatures as potential biomarkers in clinical mass spectrometry

R Mnatsakanyan, G Shema, M Basik… - Expert Review of …, 2018 - Taylor & Francis
Introduction: Numerous diseases are caused by changes in post-translational modifications
(PTMs). Therefore, the number of clinical proteomics studies that include the analysis of …

Proteomics analysis of human tears from aqueous-deficient and evaporative dry eye patients

N Perumal, S Funke, N Pfeiffer, FH Grus - Scientific reports, 2016 - nature.com
Despite the high global prevalence of dry eye syndrome (DES), the fundamental processes
underlying this pathology remain largely unexplored. Therefore, this study endeavoured to …

Towards building a quantitative proteomics toolbox in precision medicine: a mini-review

A Correa Rojo, D Heylen, J Aerts, O Thas… - Frontiers in …, 2021 - frontiersin.org
Precision medicine as a framework for disease diagnosis, treatment, and prevention at the
molecular level has entered clinical practice. From the start, genetics has been an …

Homogeneous biosensing based on magnetic particle labels

S Schrittwieser, B Pelaz, WJ Parak, S Lentijo-Mozo… - Sensors, 2016 - mdpi.com
The growing availability of biomarker panels for molecular diagnostics is leading to an
increasing need for fast and sensitive biosensing technologies that are applicable to point-of …

Mass spectrometry-assisted gel-based proteomics in cancer biomarker discovery: approaches and application

R Huang, Z Chen, L He, N He, Z **, Z Li, Y Deng… - …, 2017 - pmc.ncbi.nlm.nih.gov
There is a critical need for the discovery of novel biomarkers for early detection and targeted
therapy of cancer, a major cause of deaths worldwide. In this respect, proteomic …

Clinical proteomics towards multiomics in cancer

CJ Creighton - Mass Spectrometry Reviews, 2024 - Wiley Online Library
Recent technological advancements in mass spectrometry (MS)‐based proteomics
technologies have accelerated its application to study greater and greater numbers of …

Recent advances in salivary cancer diagnostics enabled by biosensors and bioelectronics

S Mishra, D Saadat, O Kwon, Y Lee, WS Choi… - Biosensors and …, 2016 - Elsevier
There is a high demand for a non-invasive, rapid, and highly accurate tool for disease
diagnostics. Recently, saliva based diagnostics for the detection of specific biomarkers has …

Proteomics of human mitochondria

J Palmfeldt, P Bross - Mitochondrion, 2017 - Elsevier
Proteomics have passed through a tremendous development in the recent years by the
development of ever more sensitive, fast and precise mass spectrometry methods. The …

Probing the colorectal cancer proteome for biomarkers: Current status and perspectives

PY Lee, SF Chin, TY Low, R Jamal - Journal of proteomics, 2018 - Elsevier
Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide. Biomarkers
that can facilitate better clinical management of CRC are in high demand to improve patient …