The advent of ribosome profiling and other tools to probe mRNA translation has revealed
that codon bias—the uneven use of synonymous codons in the transcriptome—serves as a …

Despite their name, synonymous mutations have significant consequences for cellular
processes in all taxa. As a result, an understanding of codon bias is central to fields as …

Reconstruction of target genomes from sequence data produced by instruments that are
agnostic as to the species-of-origin may be confounded by contaminant DNA. Whether …

Genomic DNA base composition (GC content) is predicted to significantly affect genome
functioning and species ecology. Although several hypotheses have been put forward to …

The Escherichia coli species represents one of the best-studied model organisms, but also
encompasses a variety of commensal and pathogenic strains that diversify by high rates of …

Recombination is typically thought of as a symmetrical process resulting in large-scale
reciprocal genetic exchanges between homologous chromosomes. Recombination events …

The nature and scale of recombination rate variation are largely unknown for most species.
In humans, pedigree analysis has documented variation at the chromosomal level, and …

Although the assumption of the neutral theory of molecular evolution—that some classes of
mutation have too small an effect on fitness to be affected by natural selection—seems …

The vast amount of data generated by genome projects and the recent development of
population genetics models make comparative sequence analyses a very powerful …

Theileria parasites infect a wide range of domestic and wild ruminants worldwide, causing
diseases with varying degrees of severity. A broad classification, based on the parasite's …