Hydrogels as functional components in artificial cell systems

ME Allen, JW Hindley, DK Baxani, O Ces… - Nature Reviews …, 2022 - nature.com
Recent years have seen substantial efforts aimed at constructing artificial cells from various
molecular components with the aim of mimicking the processes, behaviours and …

Current state of knowledge on intelligent-response biological and other macromolecular hydrogels in biomedical engineering: A review

M Su, L Ruan, X Dong, S Tian, W Lang, M Wu… - International Journal of …, 2023 - Elsevier
Because intelligent hydrogels have good biocompatibility, a rapid response, and good
degradability as well as a stimulus response mode that is rich, hydrophilic, and similar to the …

Reaction–diffusion patterning of DNA-based artificial cells

A Leathers, M Walczak, RA Brady… - Journal of the …, 2022 - ACS Publications
Biological cells display complex internal architectures with distinct micro environments that
establish the chemical heterogeneity needed to sustain cellular functions. The continued …

Nucleic acid liquids

GR Abraham, AS Chaderjian… - Reports on Progress …, 2024 - iopscience.iop.org
The confluence of recent discoveries of the roles of biomolecular liquids in living systems
and modern abilities to precisely synthesize and modify nucleic acids (NAs) has led to a …

Chemical and biological engineering strategies to make and modify next-generation hydrogel biomaterials

R Gharios, RM Francis, CA DeForest - Matter, 2023 - cell.com
There is a growing interest in the development of technologies to probe and direct in vitro
cellular function for fundamental organoid and stem cell biology, functional tissue and …

The ALS/FTD-related C9orf72 hexanucleotide repeat expansion forms RNA condensates through multimolecular G-quadruplexes

F Raguseo, Y Wang, J Li, M Petrić Howe… - Nature …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are
neurodegenerative diseases that exist on a clinico-pathogenetic spectrum, designated …

DNA-origami line-actants control domain organization and fission in synthetic membranes

R Rubio-Sánchez, BM Mognetti, P Cicuta… - Journal of the …, 2023 - ACS Publications
Cells can precisely program the shape and lateral organization of their membranes using
protein machinery. Aiming to replicate a comparable degree of control, here we introduce …

Self‐assembly of DNA nanostructures in different cations

A Rodriguez, D Gandavadi, J Mathivanan, T Song… - Small, 2023 - Wiley Online Library
The programmable nature of DNA allows the construction of custom‐designed static and
dynamic nanostructures, and assembly conditions typically require high concentrations of …

“Domino” cascade reactor based on DNA hydrogel for synergistic treatment of malignant tumor

X Liu, M Ma, S Tian, W Wang, X Li - European Journal of Medicinal …, 2023 - Elsevier
The action pathways of starvation therapy and photodynamic therapy (PDT) do not exist in
isolation and are usually related to tumor cell metabolism and immune regulation, which are …

Sculpting DNA-based synthetic cells through phase separation and phase-targeted activity

L Malouf, DA Tanase, G Fabrini, RA Brady… - Chem, 2023 - cell.com
Synthetic cells, like their biological counterparts, require internal compartments with distinct
chemical and physical properties where different functionalities can be localized. Inspired by …