Nicotinamide adenine dinucleotide (NAD), the cell's hydrogen carrier for redox enzymes, is
well known for its role in redox reactions. More recently, it has emerged as a signaling …

Axons are electrically excitable, cable-like neuronal processes that relay information
between neurons within the nervous system and between neurons and peripheral target …

Axon degeneration is an intrinsic self-destruction program that underlies axon loss during
injury and disease. Sterile alpha and TIR motif–containing 1 (SARM1) protein is an essential …

Peripheral polyneuropathy is a common and dose-limiting side effect of many important
chemotherapeutic agents. Most such neuropathies are characterized by early axonal …

Axon degeneration is an evolutionarily conserved pathway that eliminates damaged or
unneeded axons. Manipulation of this poorly understood pathway may allow treatment of a …

A wide range of insults can trigger axon degeneration, and axons respond with diverse
morphology, topology and speed. However, recent genetic, immunochemical, morphological …

Traditionally, researchers have believed that axons are highly dependent on their cell
bodies for long-term survival. However, recent studies point to the existence of axon …

Wallerian degeneration (WD) is the set of molecular and cellular events by which
degenerating axons and myelin are cleared after injury. Why WD is rapid and robust in the …

The P7C3 class of aminopropyl carbazole chemicals fosters the survival of neurons in a
variety of rodent models of neurodegeneration or nerve cell injury. To uncover its …

Axons and their synapses distal to an injury undergo rapid Wallerian degeneration, but
axons in the C57BL/Wld S mouse are protected. The degenerative and protective …