C-tactile afferents: Cutaneous mediators of oxytocin release during affiliative tactile interactions?

SC Walker, PD Trotter, WT Swaney, A Marshall… - Neuropeptides, 2017 - Elsevier
Low intensity, non-noxious, stimulation of cutaneous somatosensory nerves has been
shown to trigger oxytocin release and is associated with increased social motivation, plus …

Oxytocin and pain perception: from animal models to human research

S Boll, ACA De Minas, A Raftogianni, SC Herpertz… - Neuroscience, 2018 - Elsevier
An accumulating body of evidence suggests that the hypothalamic neuropeptide oxytocin
(OT) has a modulatory effect on pain processing. Particularly strong evidence comes from …

Oxytocin signaling in pain: cellular, circuit, system, and behavioral levels

P Poisbeau, V Grinevich, A Charlet - Behavioral pharmacology of …, 2018 - Springer
Originally confined to the initiation of parturition and milk ejection after birth, the
hypothalamic nonapeptide oxytocin (OT) is now recognized as a critical determinant of …

Oxytocin and the modulation of pain experience: Implications for chronic pain management

LM Tracy, N Georgiou-Karistianis, SJ Gibson… - Neuroscience & …, 2015 - Elsevier
In an acute environment pain has potential protective benefits. However when pain
becomes chronic this protective effect is lost and the pain becomes an encumbrance …

[HTML][HTML] Oxytocin, erectile function and sexual behavior: last discoveries and possible advances

MR Melis, A Argiolas - International journal of molecular sciences, 2021 - mdpi.com
A continuously increasing amount of research shows that oxytocin is involved in numerous
central functions. Among the functions in which oxytocin is thought to be involved are those …

The analgesic effects of oxytocin in the peripheral and central nervous system

Q **n, B Bai, W Liu - Neurochemistry International, 2017 - Elsevier
Pain is a ubiquitously unpleasant feeling among humans as well as many animal species
often caused by actual and potential tissue damage. However, it is absolutely crucial for our …

Chronic oxytocin administration as a tool for investigation and treatment: A cross-disciplinary systematic review

M Horta, K Kaylor, D Feifel, NC Ebner - Neuroscience & Biobehavioral …, 2020 - Elsevier
Oxytocin (OT) subserves various physiological, behavioral, and cognitive processes. This
paired with the ability to administer OT with minimal and inconsistent side effects has …

The analgesic effect of oxytocin in humans: a double‐blind, placebo‐controlled cross‐over study using laser‐evoked potentials

Y Paloyelis, C Krahé, S Maltezos… - Journal of …, 2016 - Wiley Online Library
Oxytocin is a neuropeptide regulating social‐affiliative and reproductive behaviour in
mammals. Despite robust preclinical evidence for the antinociceptive effects and …

Effects of intranasal oxytocin on pain perception among human subjects: A systematic literature review and meta-analysis

S Lopes, F de Lima Osório - Hormones and Behavior, 2023 - Elsevier
Introduction Oxytocin (OXT) is a peptide hormone produced in the hypothalamus that plays a
neuromodulatory role in emotion, stress, and anxiety. Due to its multidimensional role, OXT …

Evaluating the efficacy of oxytocin for pain management: An updated systematic review and meta-analysis of randomized clinical trials and observational studies

AA Mekhael, JE Bent, JM Fawcett… - Canadian Journal of …, 2023 - Taylor & Francis
Background There is a need for novel analgesics with favorable risk to benefit profiles.
Oxytocin has recently gained attention for its potential analgesic properties. Aim The aim of …