Genome-wide association studies in plant pathosystems: success or failure?

C Demirjian, F Vailleau, R Berthomé, F Roux - Trends in plant science, 2023 - cell.com
Harnessing natural genetic variation is an established alternative to artificial genetic
variation for investigating the molecular dialog between partners in plant pathosystems …

The causes and consequences of genetic interactions (epistasis)

J Domingo, P Baeza-Centurion… - Annual review of …, 2019 - annualreviews.org
The same mutation can have different effects in different individuals. One important reason
for this is that the outcome of a mutation can depend on the genetic context in which it …

Genomic investigation of 18,421 lines reveals the genetic architecture of rice

X Wei, M Chen, Q Zhang, J Gong, J Liu, K Yong… - Science, 2024 - science.org
Understanding how numerous quantitative trait loci (QTL) shape phenotypic variation is an
important question in genetics. To address this, we established a permanent population of …

Systematic analysis of complex genetic interactions

E Kuzmin, B VanderSluis, W Wang, G Tan… - Science, 2018 - science.org
INTRODUCTION Genetic interactions occur when mutations in different genes combine to
result in a phenotype that is different from expectation based on those of the individual …

Application of deep learning methods in biological networks

S **, X Zeng, F **e on phenotype.
With whole-genome sequence information available for thousands of individuals within a …

Advances in genome-wide association studies of complex traits in rice

Q Wang, J Tang, B Han, X Huang - Theoretical and Applied Genetics, 2020 - Springer
Genome-wide association studies (GWAS), genetic surveys of the whole genome to detect
variants associated with a trait in natural populations, are a powerful approach for dissecting …

Barcoded bulk QTL map** reveals highly polygenic and epistatic architecture of complex traits in yeast

ANN Ba, KR Lawrence, A Rego-Costa… - Elife, 2022 - elifesciences.org
Map** the genetic basis of complex traits is critical to uncovering the biological
mechanisms that underlie disease and other phenotypes. Genome-wide association studies …

Environmental robustness of the global yeast genetic interaction network

M Costanzo, J Hou, V Messier, J Nelson, M Rahman… - Science, 2021 - science.org
INTRODUCTION Genetic interactions are identified when variants in different genes
combine to generate an unusual phenotype compared with the expected combined effect of …

Deep learning versus parametric and ensemble methods for genomic prediction of complex phenotypes

R Abdollahi-Arpanahi, D Gianola… - Genetics Selection …, 2020 - Springer
Background Transforming large amounts of genomic data into valuable knowledge for
predicting complex traits has been an important challenge for animal and plant breeders …