Inflammasomes are molecular platforms that assemble upon sensing various intracellular
stimuli. Inflammasome assembly leads to activation of caspase 1, thereby promoting the …

Increasing evidence suggests that renal inflammation contributes to the pathogenesis and
progression of diabetic kidney disease (DKD) and that anti-inflammatory therapies might …

Significance: Inflammasomes are multiprotein complexes localized within the cytoplasm of
the cell that are responsible for the maturation of proinflammatory cytokines such as …

The NOD-like receptor (NLR) family of proteins is a group of pattern recognition receptors
(PRRs) known to mediate the initial innate immune response to cellular injury and stress …

Acute kidney injury (AKI) is a global public health concern associated with high morbidity,
mortality, and healthcare costs. Other than dialysis, no therapeutic interventions reliably …

Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …

The kidneys are frequently targeted by pathogenic immune responses against renal
autoantigens or by local manifestations of systemic autoimmunity. Recent studies in rodent …

An intense, stereotyped inflammatory response occurs in response to ischaemic and non-
ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein …

Fibrosis is the final common pathway of inflammatory diseases in various organs. The
inflammasomes play an important role in the progression of fibrosis as innate immune …

The production of various reactive oxidant species in excess of endogenous antioxidant
defense mechanisms promotes the development of a state of oxidative stress, with …