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SARS-CoV-2 variant biology: immune escape, transmission and fitness
In late 2020, after circulating for almost a year in the human population, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibited a major step change in its …
respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibited a major step change in its …
Omicron: what makes the latest SARS-CoV-2 variant of concern so concerning?
Emerging strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the
causative agent of the coronavirus disease 2019 (COVID-19) pandemic, that show …
causative agent of the coronavirus disease 2019 (COVID-19) pandemic, that show …
SARS-CoV-2-specific T cells in the changing landscape of the COVID-19 pandemic
Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, multiple severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increasing ability to …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increasing ability to …
SARS-CoV-2 mutations and their impact on diagnostics, therapeutics and vaccines
S Thakur, S Sasi, SG Pillai, A Nag, D Shukla… - Frontiers in …, 2022 - frontiersin.org
With the high rate of COVID-19 infections worldwide, the emergence of SARS-CoV-2
variants was inevitable. Several mutations have been identified in the SARS-CoV-2 …
variants was inevitable. Several mutations have been identified in the SARS-CoV-2 …
An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease
Y Peng, SL Felce, D Dong, F Penkava, AJ Mentzer… - Nature …, 2022 - nature.com
Abstract NP105–113-B* 07: 02-specific CD8+ T cell responses are considered among the
most dominant in SARS-CoV-2-infected individuals. We found strong association of this …
most dominant in SARS-CoV-2-infected individuals. We found strong association of this …
In search of a pan-coronavirus vaccine: Next-generation vaccine design and immune mechanisms
S Cankat, MU Demael, L Swadling - Cellular & molecular immunology, 2024 - nature.com
Members of the coronaviridae family are endemic to human populations and have caused
several epidemics and pandemics in recent history. In this review, we will discuss the …
several epidemics and pandemics in recent history. In this review, we will discuss the …
Understanding the role of SARS-CoV-2 ORF3a in viral pathogenesis and COVID-19
The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-
19-related morbidity and mortality, and the high mutability of the virus. One of the major …
19-related morbidity and mortality, and the high mutability of the virus. One of the major …
Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunity
SARS-CoV-2 variants that escape neutralization and potentially affect vaccine efficacy have
emerged. T cell responses play a role in protection from reinfection and severe disease, but …
emerged. T cell responses play a role in protection from reinfection and severe disease, but …
[HTML][HTML] Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope
We studied the prevalent cytotoxic CD8 T cell response mounted against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike glycoprotein 269-277 epitope …
respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike glycoprotein 269-277 epitope …
[HTML][HTML] Impact of SARS-CoV-2 exposure history on the T cell and IgG response
R Keeton, MB Tincho, A Suzuki, N Benede… - Cell Reports …, 2023 - cell.com
Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposures, from
infection or vaccination, can potently boost spike antibody responses. Less is known about …
infection or vaccination, can potently boost spike antibody responses. Less is known about …