Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …

Lipid phosphoinositides are master regulators of almost all aspects of a cell's life and death
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Lipid phosphoinositides play fundamental roles in virtually all pathways that control a cell's
decision to grow, move, divide, and die. Because of this, kinases that phosphorylate …

Although Alzheimer's disease is the most pervasive neurodegenerative disorder, the
mechanism underlying its development is still not precisely understood. Available data …

The regulation of autophagy-dependent lysosome homeostasis in vivo is unclear. We
showed that the inositol polyphosphate 5-phosphatase INPP5K regulates autophagic …

Phosphatidylinositol (PI) regulating enzymes are frequently altered in cancer and have
become a focus for drug development. Here, we explore the phosphatidylinositol-5 …

Lysosomes play major roles in growth regulation and catabolism and are recognized as
critical mediators of cellular remodeling. An emerging theme is how the lysosome is itself …

Phosphoinositides are essential signaling molecules. The PI5P4K family of
phosphoinositide kinases and their substrates and products, PI5P and PI4, 5P2 …

Meat quality has an important genetic component and can be modified by the fatty acid (FA)
composition and the amount of fat contained in adipose tissue and muscle. The present …