Research evidence indicating common metabolic mechanisms through which type 2
diabetes mellitus (T2DM) increases risk of late-onset Alzheimer's dementia (LOAD) has …

Diabetes mellitus (DM) is characterized by hyperglycemia either due to deficient insulin
production (Type 1 Diabetes mellitus) or peripheral insulin resistance of the cells (Type 2 …

Hoy en día," discapacidad" es un término neutral que abarca las deficiencias en las
funciones y estructuras corporales, las limitaciones en la capacidad de llevar a cabo …

Diabetes mellitus (DM) is considered a risk factor for the development of Alzheimer disease
(AD); however, how DM favors evolution of AD is still insufficiently understood …

Introduction Alzheimer's disease (AD) is the major cause of dementia among the elderly.
Finding blood-based biomarkers for disease diagnosis and prognosis is urgently needed …

Background and objective In the last few decades we have witnessed an interesting
transformation of the population pyramids throughout the world. As the population's life …

Although the association between type 2 diabetes and dementia is recognized, findings from
the epidemiology literature on the effect of insulin and one of its side effects, hypoglycemia …

Apolipoprotein E (A po E) is a major lipid carrier protein. In humans, A po E is expressed in
three polymorphic isoforms, which are encoded by three different alleles APOE 2, APOE 3 …

Background and objective Cognitive impairment and dementia are common geriatric
syndromes in diabetic patients. Inflammation plays a crucial role in the pathophysiology of …

Appendix KExcluded clinical studies Exclusion criteria Studies with mixed population of the
following and no subgroup analyses of adults or young people: Children and young people (less …