RNA-binding proteins in cancer: old players and new actors
RNA-binding proteins (RBPs) are key players in post-transcriptional events. The
combination of versatility of their RNA-binding domains with structural flexibility enables …
combination of versatility of their RNA-binding domains with structural flexibility enables …
RNA-binding proteins in human genetic disease
RNA-binding proteins (RBPs) are key components in RNA metabolism, regulating the
temporal, spatial and functional dynamics of RNAs. Altering the expression of RBPs has …
temporal, spatial and functional dynamics of RNAs. Altering the expression of RBPs has …
Cancer the 'RBP'eutics–RNA-binding proteins as therapeutic targets for cancer
RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …
including splicing, cleavage and polyadenylation, transport, translation and degradation of …
EMT in cervical cancer: its role in tumour progression and response to therapy
The prognosis of cervical patients significantly decreases as the cancer metastasizes to
other parts of the body. The epithelial to mesenchymal transition (EMT) plays an important …
other parts of the body. The epithelial to mesenchymal transition (EMT) plays an important …
[HTML][HTML] RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer
Traditionally majority of eukaryotic gene expression is influenced by transcriptional and post-
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …
Alternative splicing in prostate cancer
A Paschalis, A Sharp, JC Welti, A Neeb… - Nature reviews Clinical …, 2018 - nature.com
Androgen receptor (AR) splice variants (AR-Vs) have been implicated in the development
and progression of metastatic prostate cancer. AR-Vs are truncated isoforms of the AR, a …
and progression of metastatic prostate cancer. AR-Vs are truncated isoforms of the AR, a …
Alternative splicing and cell survival: from tissue homeostasis to disease
Most human genes encode multiple mRNA variants and protein products through alternative
splicing of exons and introns during pre-mRNA processing. In this way, alternative splicing …
splicing of exons and introns during pre-mRNA processing. In this way, alternative splicing …
Oncogenic activation of the RNA binding protein NELFE and MYC signaling in hepatocellular carcinoma
Global transcriptomic imbalance is a ubiquitous feature associated with cancer, including
hepatocellular carcinoma (HCC). Analyses of 1,225 clinical HCC samples revealed that a …
hepatocellular carcinoma (HCC). Analyses of 1,225 clinical HCC samples revealed that a …
The RNA splicing response to DNA damage
The number of factors known to participate in the DNA damage response (DDR) has
expanded considerably in recent years to include splicing and alternative splicing factors …
expanded considerably in recent years to include splicing and alternative splicing factors …
[HTML][HTML] RNA binding protein as an emerging therapeutic target for cancer prevention and treatment
S Hong - Journal of cancer prevention, 2017 - ncbi.nlm.nih.gov
After transcription, RNAs are always associated with RNA binding proteins (RBPs) to
perform biological activities. RBPs can interact with target RNAs in sequence-and structure …
perform biological activities. RBPs can interact with target RNAs in sequence-and structure …