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Nrf2 signaling pathway in cisplatin chemotherapy: Potential involvement in organ protection and chemoresistance
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a vital transcription factor and its induction
is of significant importance for protecting against oxidative damage. Increased levels of …
is of significant importance for protecting against oxidative damage. Increased levels of …
Targeting NRF2 and its downstream processes: opportunities and challenges
The transcription factor NRF2 coordinates the expression of a vast array of cytoprotective
and metabolic genes in response to various stress inputs to restore cellular homeostasis …
and metabolic genes in response to various stress inputs to restore cellular homeostasis …
Pharmacological activities, therapeutic effects, and mechanistic actions of trigonelline
Trigonelline (TRG) is a natural polar hydrophilic alkaloid that is found in many plants such as
green coffee beans and fenugreek seeds. TRG potentially acts on multiple molecular …
green coffee beans and fenugreek seeds. TRG potentially acts on multiple molecular …
The interplay of oncogenic signaling, oxidative stress and ferroptosis in cancer
Oncogene‐induced hyper‐proliferation in cancer cells is accompanied by the onset of
different stresses, including DNA‐replication stress, metabolic stress and oxidative stress …
different stresses, including DNA‐replication stress, metabolic stress and oxidative stress …
Integrated analysis of colorectal cancer reveals cross-cohort gut microbial signatures and associated serum metabolites
Background & Aims Studies have reported abnormal gut microbiota or circulating
metabolome associated with colorectal cancer (CRC), but it remains a challenge to capture …
metabolome associated with colorectal cancer (CRC), but it remains a challenge to capture …
Targeting multidrug resistance-associated protein 1 (MRP1)-expressing cancers: Beyond pharmacological inhibition
Resistance to chemotherapy remains one of the most significant obstacles to successful
cancer treatment. While inhibiting drug efflux mediated by ATP-binding cassette (ABC) …
cancer treatment. While inhibiting drug efflux mediated by ATP-binding cassette (ABC) …
Risk assessment of trigonelline in coffee and coffee by-products
N Konstantinidis, H Franke, S Schwarz… - Molecules, 2023 - mdpi.com
Trigonelline is a bioactive pyridine alkaloid that occurs naturally in high concentrations in
coffee (up to 7.2 g/kg) and coffee by-products (up to 62.6 g/kg) such as coffee leaves …
coffee (up to 7.2 g/kg) and coffee by-products (up to 62.6 g/kg) such as coffee leaves …
The neuroprotective and antidiabetic effects of trigonelline: A review of signaling pathways and molecular mechanisms
Y Liang, X Dai, Y Cao, X Wang, J Lu, L **e, K Liu, X Li - Biochimie, 2023 - Elsevier
The global epidemic of diabetes has brought heavy pressure on public health. New effective
anti-diabetes strategies are urgently needed. Trigonelline is the main component of …
anti-diabetes strategies are urgently needed. Trigonelline is the main component of …
Bioactive compounds in coffee and their role in lowering the risk of major public health consequences: A review
This article addresses the bioactive components in coffee aroma, their metabolism, and the
mechanism of action in lowering the risk of various potential health problems. The main …
mechanism of action in lowering the risk of various potential health problems. The main …
Health benefits of coffee consumption for cancer and other diseases and mechanisms of action
Coffee is one of the most widely consumed beverages worldwide, and epidemiology studies
associate higher coffee consumption with decreased rates of mortality and decreased rates …
associate higher coffee consumption with decreased rates of mortality and decreased rates …