Astrocytes in human central nervous system diseases: a frontier for new therapies

A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - Signal transduction and …, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

The blood-brain barrier in aging and neurodegeneration

EG Knox, MR Aburto, G Clarke, JF Cryan… - Molecular …, 2022 - nature.com
The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an
exquisite control of exchange of compounds between the blood and the brain parenchyma …

Multisensory gamma stimulation promotes glymphatic clearance of amyloid

MH Murdock, CY Yang, N Sun, PC Pao… - Nature, 2024 - nature.com
The glymphatic movement of fluid through the brain removes metabolic waste,,–.
Noninvasive 40 Hz stimulation promotes 40 Hz neural activity in multiple brain regions and …

Astrocyte endfeet in brain function and pathology: open questions

B Díaz-Castro, S Robel, A Mishra - Annual review of …, 2023 - annualreviews.org
Astrocyte endfeet enwrap the entire vascular tree within the central nervous system, where
they perform important functions in regulating the blood-brain barrier (BBB), cerebral blood …

Functional analysis of the human perivascular subarachnoid space

PK Eide, G Ringstad - Nature Communications, 2024 - nature.com
The human subarachnoid space harbors the cerebrospinal fluid, which flows within a
landscape of blood vessels and trabeculae. Functional implications of subarachnoid space …

Inflammation from peripheral organs to the brain: how does systemic inflammation cause neuroinflammation?

Y Sun, Y Koyama, S Shimada - Frontiers in aging neuroscience, 2022 - frontiersin.org
As inflammation in the brain contributes to several neurological and psychiatric diseases,
the cause of neuroinflammation is being widely studied. The causes of neuroinflammation …

Fluid transport in the brain

MK Rasmussen, H Mestre… - Physiological …, 2022 - journals.physiology.org
The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

The glymphatic system: Current understanding and modeling

T Bohr, PG Hjorth, SC Holst, S Hrabětová, V Kiviniemi… - IScience, 2022 - cell.com
We review theoretical and numerical models of the glymphatic system, which circulates
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …

The glymphatic system: implications for drugs for central nervous system diseases

TJ Lohela, TO Lilius, M Nedergaard - Nature Reviews Drug Discovery, 2022 - nature.com
In the past decade, evidence for a fluid clearance pathway in the central nervous system
known as the glymphatic system has grown. According to the glymphatic system concept …

The glymphatic system: a novel component of fundamental neurobiology

LM Hablitz, M Nedergaard - Journal of Neuroscience, 2021 - jneurosci.org
Throughout the body, lymphatic fluid movement supports critical functions including
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …