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Learning the regulatory code of gene expression
Data-driven machine learning is the method of choice for predicting molecular phenotypes
from nucleotide sequence, modeling gene expression events including protein-DNA …
from nucleotide sequence, modeling gene expression events including protein-DNA …
Deep learning-based codon optimization with large-scale synonymous variant datasets enables generalized tunable protein expression
Increasing recombinant protein expression is of broad interest in industrial biotechnology,
synthetic biology, and basic research. Codon optimization is an important step in …
synthetic biology, and basic research. Codon optimization is an important step in …
Predicting gene sequences with AI to study codon usage patterns
Selective pressure acts on the codon use, optimizing multiple, overlap** signals that are
only partially understood. We trained AI models to predict codons given their amino acid …
only partially understood. We trained AI models to predict codons given their amino acid …
CodonTransformer: a multispecies codon optimizer using context-aware neural networks
The genetic code is degenerate allowing a multitude of possible DNA sequences to encode
the same protein. This degeneracy impacts the efficiency of heterologous protein production …
the same protein. This degeneracy impacts the efficiency of heterologous protein production …
Pre-trained protein language model for codon optimization
Abstract Motivation Codon optimization of Open Reading Frame (ORF) sequences is
essential for enhancing mRNA stability and expression in applications like mRNA vaccines …
essential for enhancing mRNA stability and expression in applications like mRNA vaccines …
Natural Language Processing for Language of Life (mRNA vaccine design)
S Pathak - 2024 - era.library.ualberta.ca
The COVID-19 pandemic accelerated the development of mRNA vaccines, yet identifying
the optimal mRNA sequence for human use, particularly for the SARS-CoV-2 spike protein …
the optimal mRNA sequence for human use, particularly for the SARS-CoV-2 spike protein …