Biomolecular condensates, formed through phase separation, are upending our
understanding in much of molecular, cell, and developmental biology. There is an urgent …

Phase separation, crucial for spatially segregating biomolecules in cells, is well-understood
in the simple case of a few components with pairwise interactions. Yet, biological cells …

Cytosolic aggregation of the nuclear protein TDP-43 is associated with many
neurodegenerative diseases, but the triggers for TDP-43 aggregation are still debated. Here …

Multidomain proteins with long flexible linkers and full-length intrinsically disordered
proteins (IDPs) are best defined as an ensemble of conformations rather than a single …

Motivation Characterizing the structure of flexible proteins, particularly within the realm of
intrinsic disorder, presents a formidable challenge due to their high conformational …

A molecular grammar governing low-complexity prion-like domain phase separation (PS)
has identified tyrosine and arginine as primary drivers via aromatic–aromatic and aromatic …

The transactive response DNA binding protein 43 (TDP-43) is an RNA/DNA-binding protein
that is involved in a number of cellular functions, including RNA processing and alternative …

The primarily disordered C-terminal domain (CTD) of TAR DNA binding protein-43 (TDP-
43), a key nuclear protein in RNA metabolism, forms neuronal inclusions in several …

The aberrant aggregation of TAR DNA-binding protein 43 kDa (TDP-43) in cells leads to the
pathogenesis of multiple fatal neurodegenerative diseases. Decoding the proposed initial …

A molecular grammar governing low-complexity prion-like domains phase separation (PS)
has been proposed based on mutagenesis experiments that identified tyrosine and arginine …