Adenosine signalling has long been a target for drug development, with adenosine itself or
its derivatives being used clinically since the 1940s. In addition, methylxanthines such as …

Recombinant viruses are the workhorse of modern neuroscience. Whether one would like to
understand a neuron's morphology, natural activity patterns, molecular composition …

Microglia, the brain's resident macrophages, help to regulate brain function by removing
dying neurons, pruning non-functional synapses, and producing ligands that support …

In the 10 years since our previous International Union of Basic and Clinical Pharmacology
report on the nomenclature and classification of adenosine receptors, no developments …

Molecular pathways mediating systemic inflammation entering the brain parenchyma to
induce sepsis-associated encephalopathy (SAE) remain elusive. Here, we report that in …

Mice experiencing repeated aggression develop a long-lasting aversion to social contact,
which can be normalized by chronic, but not acute, administration of antidepressant. Using …

We used a knock-in strategy to generate two lines of mice expressing Cre recombinase
under the transcriptional control of the dopamine transporter promoter (DAT-cre mice) or the …

To identify the role of the histone acetyltransferase (HAT) CREB-binding protein (CBP) in
neurons of the CA1 region of the hippocampus during memory formation, we examine the …

▪ Abstract Adenosine and its receptors have been the topic of many recent reviews (–).
These reviews provide a good summary of much of the relevant literature—including the …

The CB1 cannabinoid receptor, the main molecular target of endocannabinoids and
cannabis active components, is the most abundant G protein-coupled receptor in the …