Recently, a number of clinical studies have explored links between possible Relative
Biological Effectiveness (RBE) elevations and patient toxicities and/or image changes …

Proton beam therapy is a highly conformal form of radiation therapy, which currently
represents an important therapeutic component in multidisciplinary management in …

Two thirds of pediatric gliomas are classified as low-grade (LGG), while in adults only
around 20% of gliomas are low-grade. However, these tumors do not only differ in their …

Purpose The aim of this study was to comprehensively review all studies examining clinical
outcomes of craniospinal irradiation with proton radiotherapy for medulloblastoma (MB) to …

Background: Gliomas are primary cerebral tumors. Radiation therapy plays a key role in
their treatment but with a risk of toxicity associated with the dose to and volume of normal …

Background and purpose Proton beam radiotherapy (PRT) is used in the treatment of low-
grade glioma (LGG) to mitigate long-term sequelae. Following PRT, increased rates of …

Purpose Proton beam radiotherapy (PRT) has been demonstrated to improve
neurocognitive sequelae particularly. Nevertheless, following PRT, increased rates of …

Abstract Background Pseudoprogression (PsP) following radiation therapy (RT) for low
grade glioma (LGG, WHO grade I and II), including both photon-based intensity-modulated …

Proton radiotherapy has promised an advantage in safely treating pediatric malignancies
with an increased capability to spare normal tissues, reducing the risk of both acute and late …

Pediatric low-grade glioma (pLGG) is the most common childhood brain tumor group. The
natural history, when curative resection is not possible, is one of a chronic disease with …