Impact of lineage plasticity to and from a neuroendocrine phenotype on progression and response in prostate and lung cancers
Intratumoral heterogeneity can occur via phenotype transitions, often after chronic exposure
to targeted anticancer agents. This process, termed lineage plasticity, is associated with …
to targeted anticancer agents. This process, termed lineage plasticity, is associated with …
Punctuated evolution of prostate cancer genomes
The analysis of exonic DNA from prostate cancers has identified recurrently mutated genes,
but the spectrum of genome-wide alterations has not been profiled extensively in this …
but the spectrum of genome-wide alterations has not been profiled extensively in this …
Validation and clinical utility of prostate cancer biomarkers
To improve future drug development and patient management for patients with castration-
resistant prostate cancer (CRPC), surrogate biomarkers that are linked to relevant outcomes …
resistant prostate cancer (CRPC), surrogate biomarkers that are linked to relevant outcomes …
Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity
Advanced prostate cancer initially responds to hormonal treatment, but ultimately becomes
resistant and requires more potent therapies. One mechanism of resistance observed in …
resistant and requires more potent therapies. One mechanism of resistance observed in …
HDAC inhibition impedes epithelial–mesenchymal plasticity and suppresses metastatic, castration-resistant prostate cancer
Abstract PI3K (phosphoinositide 3-kinase)/AKT and RAS/MAPK (mitogen-activated protein
kinase) pathway coactivation in the prostate epithelium promotes both epithelial …
kinase) pathway coactivation in the prostate epithelium promotes both epithelial …
RapidCaP, a Novel GEM Model for Metastatic Prostate Cancer Analysis and Therapy, Reveals Myc as a Driver of Pten-Mutant Metastasis
Genetically engineered mouse (GEM) models are a pillar of functional cancer research.
Here, we developed RapidCaP, a GEM modeling system that uses surgical injection for viral …
Here, we developed RapidCaP, a GEM modeling system that uses surgical injection for viral …
Stimulator of interferon genes protein (STING) expression in cancer cells: A tissue microarray study evaluating more than 18,000 tumors from 139 different tumor …
A Menz, J Zerneke, F Viehweger, S Büyücek, D Dum… - Cancers, 2024 - mdpi.com
Simple Summary STING is a key element in the cGAS/STING cytosolic sensing pathway and
several STING agonists are currently being evaluated as anticancer drugs in the field of …
several STING agonists are currently being evaluated as anticancer drugs in the field of …
Blood-derived biomarkers of diagnosis, prognosis and therapy response in prostate cancer patients
K Balázs, L Antal, G Safrany, K Lumniczky - Journal of Personalized …, 2021 - mdpi.com
Prostate cancer is among the most frequent cancers in men worldwide. Despite the fact that
multiple therapeutic alternatives are available for its treatment, it is often discovered in an …
multiple therapeutic alternatives are available for its treatment, it is often discovered in an …
Photothermal therapy of papillary thyroid cancer tumor xenografts with targeted thyroid stimulating hormone receptor antibody functionalized multiwalled carbon …
Multiwalled carbon nanotubes (MWCNTs) are being widely investigated in multiple
biomedical applications including, and not limited to, drug delivery, gene therapy, imaging …
biomedical applications including, and not limited to, drug delivery, gene therapy, imaging …
[HTML][HTML] Genetic progression of high grade prostatic intraepithelial neoplasia to prostate cancer
Background Although high grade prostatic intraepithelial neoplasia (HGPIN) is considered a
neoplastic lesion that precedes prostate cancer (PCA), the genomic structures of HGPIN …
neoplastic lesion that precedes prostate cancer (PCA), the genomic structures of HGPIN …