The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

The Adhesion family forms a large branch of the pharmacologically important superfamily of
G protein–coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention …

The~ 100 MB genome of C. elegans codes for~ 20,000 protein-coding genes many of which
are required for the function of the nervous system, composed of 302 neurons in the adult …

Adhesion-type heterotrimeric guanine nucleotide–binding protein (G protein)–coupled
receptors (Adhesion-GPCRs) comprise a class of widely distributed seven-transmembrane …

G protein-coupled receptors (GPCRs) mediate responses to various extracellular and
intracellular cues. However, the large number of GPCR genes and their substantial …

Abstract Cadherin-13 (CDH13), a unique glycosylphosphatidylinositol-anchored member of
the cadherin family of cell adhesion molecules, has been identified as a risk gene for …

Adhesion G protein-coupled receptors (aGPCRs) are a large GPCR class that direct diverse
fundamental biological processes. One prominent mechanism for aGPCR agonism involves …

Planar cell polarity (PCP) is complementary to the intrinsic polarization of single cells and
refers to the global coordination of cell behaviour in the plane of a tissue and, by extension …

Members of the adhesion G protein-coupled receptor (aGPCR) class have emerged as
crucial regulators of nervous system development, with important implications for human …

The signaling mechanisms that choreograph the assembly of the highly asymmetric pre-and
postsynaptic structures are still poorly defined. Using synaptosome fractionation …