Single-photon avalanche diode (SPAD) arrays are solid-state detectors that offer imaging
capabilities at the level of individual photons, with unparalleled photon counting and time …

Fluorescence correlation spectroscopy (FCS) is a powerful technique for quantification of
molecular dynamics, and it has been widely applied in diverse fields, eg, biomedicine …

This paper is intended to give a comprehensive review of light-sheet (LS) microscopy from
an optics perspective. As such, emphasis is placed on the advantages that LS microscope …

Single-molecule biophysics has transformed our understanding of biology, but also of the
physics of life. More exotic than simple soft matter, biomatter lives far from thermal …

Single-plane illumination (SPIM) or total internal reflection fluorescence (TIRF) microscopes
can be combined with fast and single-molecule-sensitive cameras to allow spatially resolved …

We report on the design and characterization of a multipurpose 64× 32 CMOS single-photon
avalanche diode (SPAD) array. The chip is fabricated in a high-voltage 0.35-μm CMOS …

Super-resolution microscopy and single molecule fluorescence spectroscopy require
mutually exclusive experimental strategies optimizing either temporal or spatial resolution …

An Introduction to Fluorescence Correlation Spectroscopy represents a comprehensive
introduction to fluorescence correlation spectroscopy (FCS), a biophysical experimental …

We present the architecture and three applications of the largest resolution image sensor
based on single-photon avalanche diodes (SPADs) published to date. The sensor …

Significance Fluorescence lifetime imaging microscopy (FLIM) of the metabolic co-enzyme
nicotinamide adenine dinucleotide (phosphate)[NAD (P) H] is a popular method to monitor …