Experimental diabetes induced by alloxan and streptozotocin: The current state of the art

M Radenković, M Stojanović, M Prostran - Journal of pharmacological and …, 2016 - Elsevier
Diabetes mellitus is a chronic metabolic disorder with a high prevalence worldwide. Animal
models of diabetes represent an important tool in diabetes investigation that helps us to …

Epigenetic modulation of macrophage polarization-perspectives in diabetic wounds

SB Mallik, BS Jayashree, RR Shenoy - Journal of Diabetes and its …, 2018 - Elsevier
Diabetes is a chronic metabolic disorder that poses a global burden to healthcare.
Increasing incidence of diabetes-related complications in the affected population includes a …

[HTML][HTML] Investigation of insulin resistance in the popularly used four rat models of type-2 diabetes

PC Chao, Y Li, CH Chang, JP Shieh, JT Cheng… - Biomedicine & …, 2018 - Elsevier
Animal models are widely used to develop drugs for treating diabetes mellitus (DM). Insulin
resistance (IR) is one of the main problems in type-2 DM (T2DM). Streptozotocin (STZ) is …

Evaluation of anti-diabetic activity of glycyrrhizin-loaded nanoparticles in nicotinamide-streptozotocin-induced diabetic rats

R Rani, S Dahiya, D Dhingra, N Dilbaghi… - European Journal of …, 2017 - Elsevier
Glycyrrhizin is an active constituent of the roots and rhizomes of Glycyrrhiza glabra and has
anti-hyperglycemic effects. In this study, nanoparticles (NPs) loaded with glycyrrhizin or …

In vivo dual-delivery of glucagon like peptide-1 (GLP-1) and dipeptidyl peptidase-4 (DPP4) inhibitor through composites prepared by microfluidics for diabetes therapy

F Araujo, N Shrestha, MJ Gomes, B Herranz-Blanco… - Nanoscale, 2016 - pubs.rsc.org
Oral delivery of proteins is still a challenge in the pharmaceutical field. Nanoparticles are
among the most promising carrier systems for the oral delivery of proteins by increasing their …

Evaluation and docking of indole sulfonamide as a potent inhibitor of α-glucosidase enzyme in streptozotocin–induced diabetic albino wistar rats

M Taha, S Imran, M Salahuddin, N Iqbal, F Rahim… - Bioorganic …, 2021 - Elsevier
We have synthesized new hybrid class of indole bearing sulfonamide scaffolds (1–17) as α-
glucosidase inhibitors. All scaffolds were found to be active except scaffold 17 and exhibited …

Standardization of type 1 and type 2 diabetic nephropathy models in rats: Assessment and characterization of metabolic features and renal injury

AA Kaikini, D Dhodi, S Muke… - Journal of Pharmacy …, 2020 - journals.lww.com
Background: Diabetes mellitus and its complications, such as nephropathy, represent a
global burden. Recent research focuses on develo** drugs that specifically target the …

Antihyperglycemic activity of verbenone and L-arginine in nicotinamide-streptozotocin-induced diabetic mice: in vitro and in vivo studies

H Tijjani, AM Danyaro, A Olatunde, AU Kura - Beni-Suef University Journal …, 2022 - Springer
Background Natural products are utilized globally for the management of diseases such as
diabetes mellitus. Carrot seeds are ethnobotanically used in the management of diabetes …

Rodent models for diabetes

P Rashmi, A Urmila, A Likhit, B Subhash, G Shailendra - 3 Biotech, 2023 - Springer
Diabetes mellitus (DM) is associated with many health complications and is potentially a
morbid condition. As prevalence increases at an alarming rate around the world, research …

[HTML][HTML] Unveiling ferroptosis as a promising therapeutic avenue for colorectal cancer and colitis treatment

AT Kao, CV Cabanlong, K Padilla, X Xue - Acta Pharmaceutica Sinica B, 2024 - Elsevier
Ferroptosis is a novel type of regulated cell death (RCD) involving iron accumulation and
lipid peroxidation. Since its discovery in 2012, various studies have shown that ferroptosis is …