Cell invasion into the surrounding extracellular matrix or across tissue boundaries and
endothelial barriers occurs in both physiological and pathological scenarios such as …

Tight coupling between biochemical and mechanical properties of the actin cytoskeleton
drives a large range of cellular processes including polarity establishment, morphogenesis …

Phagocytosis is a remarkably complex and versatile process: it contributes to innate
immunity through the ingestion and elimination of pathogens, while also being central to …

The actin cytoskeleton and associated motor proteins provide the driving forces for
establishing the astonishing morphological diversity and dynamics of mammalian cells …

Focal adhesion kinase (FAK) is a key regulator of growth factor receptor-and integrin-
mediated signals, governing fundamental processes in normal and cancer cells through its …

Motile cells extend a leading edge by assembling a branched network of actin filaments that
produces physical force as the polymers grow beneath the plasma membrane. A core set of …

Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with
pharmacological interventions that are associated with poor adherence and adverse effects …

Filopodia are thin, actin-rich plasma-membrane protrusions that function as antennae for
cells to probe their environment. Consequently, filopodia have an important role in cell …

The fusion of myoblasts into multinucleate syncytia plays a fundamental role in muscle
function, as it supports the formation of extended sarcomeric arrays, or myofibrils, within a …

Many features of cell behavior are regulated by Rho family GTPases, but the most profound
effects of these proteins are on the actin cytoskeleton and it was these that first drew …