The discovery of kisspeptin as a critical central regulatory factor of GnRH release has given
people a novel understanding of the neuroendocrine regulation in human reproduction …

G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling
receptors known to play a crucial role in various physiological functions, including tumor …

Gonadal hormones play a key role in the establishment, activation, and regulation of the
hypothalamic–pituitary–adrenal (HPA) axis. By influencing the response and sensitivity to …

Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two
types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research …

Reproduction is controlled by the hypothalamic-pituitary-gonadal (HPG) axis. Gonadotropin-
releasing hormone (GnRH) neurons play a central role in this axis through production of …

The platinum derivative cis-diamminedichloroplatinum (II), best known as cisplatin, is
currently employed for the clinical management of patients affected by testicular, ovarian …

During pregnancy, several tightly coordinated and regulated processes take place to enable
proper fetal development and gestational success. The formation and development of the …

BACKGROUND The discovery of kisspeptin as key central regulator of GnRH secretion has
led to a new level of understanding of the neuroendocrine regulation of human reproduction …

Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

Endometriosis and polycystic ovary syndrome (PCOS) are two common female reproductive
disorders with a significant impact on the health and quality of life of women affected. A …