primate research suggests that affiliation is a highly complex construct. studies of primate
affiliation demonstrate the need to distinguish between various affiliative behaviors, consider …

Opioid receptors are widely distributed throughout the brain and play an essential role in
modulating aspects of human mood, reward, and well-being. Accumulating evidence …

The previous two editions of the Human Nervous System have been the standard reference
for the anatomy of the central and peripheral nervous system of the human. The work has …

The κ opioid agonists are analgesics that seem to be free of undesired morphine-like effects.
Their dysphoric actions observed with the κ agonist cyclazocine are thought to be mediated …

Abstract The United States is in the midst of an opioid addiction and overdose crisis
precipitated and exacerbated by use of prescription opioid medicines. The majority of opioid …

Beginning with a brief description of mature anatomic pathways and neurotransmitters in the
“pain system,” this article details their development in the human fetus, neonate, and child …

The development of reversibly binding radioligands for imaging brain proteins in vivo, such
as enzymes, neurotransmitter transporters, receptors and ion channels, with positron …

Background: The neural mechanisms underlying the modu-lation of pain perception by
hypnosis remain obscure. In this study, we used positron emission tomography in 11 healthy …

The existence of at least three opioid receptor types, referred to as μ, κ, and δ, is well
established. Complementary DNAs corresponding to the pharmacologically defined μ, κ …

Chronic opioid exposure is known to produce neuroplastic changes in animals; however, it
is not known if opioids used over short periods of time and at analgesic dosages can …