Born to run: control of transcription elongation by RNA polymerase II
FX Chen, ER Smith, A Shilatifard - Nature reviews Molecular cell …, 2018 - nature.com
The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an
integral part of the implementation of gene expression programmes during development. In …
integral part of the implementation of gene expression programmes during development. In …
Structural insights into the functional diversity of the CDK–cyclin family
DJ Wood, JA Endicott - Open biology, 2018 - royalsocietypublishing.org
Since their characterization as conserved modules that regulate progression through the
eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are …
eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are …
Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy
JH Elliott, F Wightman, A Solomon, K Ghneim… - PLoS …, 2014 - journals.plos.org
Human immunodeficiency virus (HIV) persistence in latently infected resting memory CD4+
T-cells is the major barrier to HIV cure. Cellular histone deacetylases (HDACs) are important …
T-cells is the major barrier to HIV cure. Cellular histone deacetylases (HDACs) are important …
Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation
F Itzen, AK Greifenberg, CA Bösken… - Nucleic acids …, 2014 - academic.oup.com
The bromodomain protein Brd4 regulates the transcription of signal-inducible genes. This is
achieved by recruiting the positive transcription elongation factor P-TEFb to promoters by its …
achieved by recruiting the positive transcription elongation factor P-TEFb to promoters by its …
The molecular basis for human immunodeficiency virus latency
Although potent combination antiretroviral therapy can effectively block viral replication in
the host, human immunodeficiency virus (HIV) persists due to the existence of latent but …
the host, human immunodeficiency virus (HIV) persists due to the existence of latent but …
Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb
AJ C. Quaresma, A Bugai, M Barboric - Nucleic acids research, 2016 - academic.oup.com
Release of RNA polymerase II (Pol II) from promoter-proximal pausing has emerged as a
critical step regulating gene expression in multicellular organisms. The transition of Pol II …
critical step regulating gene expression in multicellular organisms. The transition of Pol II …
Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism
CDK9 is the kinase subunit of positive transcription elongation factor b (P-TEFb) that
enables RNA polymerase (Pol) II's transition from promoter-proximal pausing to productive …
enables RNA polymerase (Pol) II's transition from promoter-proximal pausing to productive …
HIV-1 proviral transcription and latency in the new era
A Shukla, NGP Ramirez, I D'Orso - Viruses, 2020 - mdpi.com
Three decades of extensive work in the HIV field have revealed key viral and host cell
factors controlling proviral transcription. Various models of transcriptional regulation have …
factors controlling proviral transcription. Various models of transcriptional regulation have …
Transcription: insights from the HIV-1 promoter
E Ne, RJ Palstra, T Mahmoudi - International review of cell and molecular …, 2018 - Elsevier
In this review, we cover transcription regulation of human immunodeficiency virus type 1
(HIV-1) gene expression, focusing on the invaluable contributions, made by HIV research …
(HIV-1) gene expression, focusing on the invaluable contributions, made by HIV research …
LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis
Transcriptional elongation by RNA polymerase (Pol) II is essential for gene expression
during cell growth and differentiation. The positive transcription elongation factor b (P-TEFb) …
during cell growth and differentiation. The positive transcription elongation factor b (P-TEFb) …